Dantrolene sodium salt CAS: 14663-23-1
MF: C14H9N4O5•Na
MW: 336.23
A calcium channel protein inhibitor.

Dantrolene sodium salt (CAS 14663-23-1)

Dantrolene sodium salt | CAS 14663-23-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
Application: Dantrolene sodium salt is a calcium channel protein inhibitor
CAS Number: 14663-23-1
Purity: >95%
Molecular Weight: 336.23
Molecular Formula: C14H9N4O5•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dantrolene is a small molecule inhibitor of the Ryanodine receptor and a calcium channel protein inhibitor (see Ryanodine, sc-201523). Blockade of Ca2+ release from the sarcoendoplasmic reticulum, strongly related to excitation and contraction of muscles, generates a muscle relaxant effect correlated with Dantrolene. The neurotoxicity presented by pronounced glutamate activity is correlated to excessive rises in cytoplasmic Ca2+ levels, and Dantrolene is accordingly indicated as a neuroprotective agent against neurotrasmitter-induced excitotoxicity. Dantrolene, Sodium Salt is an inhibitor of RyR-1 and RyR-3.


References

1. Ohta, T., et al. 1990. Eur. J. Pharmacol. 178: 11-19. PMID: 2332027
2. Amelink, G.J., et al. 1990. Eur. J. Pharmacol. 179: 187-192. PMID: 2364980
3. Frandsen, A., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 2590-2594. PMID: 1372982
4. Hayashi, T., et al. 1994. J. Neurochem. 63: 1849-1854. PMID: 7931341
5. Mody, I., et al. 1995. Trends Pharmacol. Sci. 16: 356-359. PMID: 7491714
6. Muehlschlegel, S., et al. 2009. Neurocrit Care. 10: 103-115. PMID: 18696266

Physical State :
Solid
Solubility :
Soluble in water (partly), 1:1 DMF:MeOH (9.80 - 10.20 mg/ml), aqueous akaline solutions, and DMSO (3 mg/ml).
Storage :
Store at room temperature
Melting Point :
279-280° C
Refractive Index :
n20D 1.72 (Predicted for the free base)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
MU3875000
PubChem CID :
Merck Index :
14: 2816
MDL Number :
MFCD00079130
EC Number :
238-706-8
SMILES :
C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-].[Na]

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Certificate of Analysis

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Dantrolene sodium salt (CAS 14663-23-1)  Product Citations

See how others have used Dantrolene sodium salt (CAS 14663-23-1). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26631534  Zhong, W. et al. 2016. Neuropharmacology. 103: 195-210.

PMID: # 25121483  Zhong, W. et al. 2014. PLoS ONE. 9: e104718.

PMID: # 18696266  Muehlschlegel, S. et al. 2009. Neurocrit Care. 10: 103-115.

PMID: # 20301529  Dunø M et al. 2005. GeneReviews. -.

PMID: # 7491714  Mody, I. et al. 1995. Trends Pharmacol. Sci. 16: 356-359.

PMID: # 7931341  Hayashi, T. et al. 1994. J. Neurochem. 63: 1849-1854.

PMID: # 8483913  Song, SK. et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 3933-3937.

PMID: # 1372982  Frandsen, A. et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 2590-2594.

PMID: # 2364980  Amelink, GJ. et al. 1990. Eur. J. Pharmacol. 179: 187-192.

PMID: # 2332027  Ohta, T. et al. 1990. Eur. J. Pharmacol. 178: 11-19.

Citations 1 to 10 of 10 total

Where I can find to find the Refractive Index value?

Asked by: AlexD
Thank you for your question. This is listed under the tab "Technical Information" (below "Ordering Information") on our website. Dantrolene sodium salt (CAS 14663-23-1) has a refractive index : n20D 1.72 (Predicted). The predicted refractive index value listed on our website was generated using https://ilab.acdlabs.com. The value listed is in reference to the non-salt form.
Answered by: Technical Support
Date published: 2017-01-10
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Rated 5 out of 5 by from Muehlschlegel et al Muehlschlegel et al. (PubMed ID 18696266) examined calcium's function as a key regulator of neural response. While studying neural injury, dantrolene sodium salt was used to inhibit calcium ion release. -SCBT Publication Review
Date published: 2015-05-26
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