Danofloxacin-d3 MesylateA labeled fluorinated quinolone antibacterial compound

Danofloxacin-d3 Mesylate (CAS 119478-55-6 (unlabeled))

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Application: A labeled fluorinated quinolone antibacterial compound
CAS Number: 119478-55-6 (unlabeled)
Molecular Weight: 456.50
Molecular Formula: C20H21D3FN3O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Danofloxacin-d3 Mesylate is a fluoroquinolone antibiotic which inhibits gram-negative bacteria. It is believed that Danofloxacin-d3 Mesylate inhibits Topo II (DNA gyrase) and triggers the activation of the SOS pathway along with temperate bacteriophages to inhibit bacterial growth. In addition, studies indicate that Danofloxacin-d3 Mesylate is a substrate for efflux-transporters such as P-gp, BCRP and MRP2, which are members of the ATP-Binding Cassette (ABC) superfamily. Ko 143 (sc-204030) can inhibit the secretion of Danofloxacin-d3 Mesylate from BCRP but does not affect its absorption. Furthermore, MK-571 (sc-201340), an inhibitor of MRPs, can increase the absorption of Danofloxacin-d3 Mesylate on the apical membrane of Caco-2 cells. Also studies suggest that Danofloxacin-d3 Mesylate shows a stronger inhibiting effect in lysogenic E. coli bearing lambda prophages than in nonlysogenic E. coli.


1. Froshauer, S., et al. 1996. Antimicrob. Agents Chemother. 40: 1561-1563. PMID: 8726041
2. Schrickx, J.A. and Fink-Gremmels, J. 2007. Br. J. Pharmacol. 150: 463-469. PMID: 17211460

Physical State :
Solubility :
Soluble in DMSO, methanol, water (91 mg/ml unlabeled) at 25° C, and ethanol (<1 mg/ml unlabeled) at 25° C.
Storage :
Store at 4° C
Melting Point :
>290° C (dec.)
Boiling Point :
569.3° C at 760 mmHg (Predicted) (unlabeled)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00673687 (unlabeled)

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Certificate of Analysis

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