DanazolA modified testosterone gonadotropin inhibitor

Danazol (CAS 17230-88-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 59ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: A modified testosterone gonadotropin inhibitor
CAS Number: 17230-88-5
Purity: ≥98%
Molecular Weight: 337.46
Molecular Formula: C22H27NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats.


References

Niwa K, Hashimoto M, Morishita S, Yokoyama Y, Lian Z, Tagami K, Mori H, Tamaya T. Cancer Lett. 158:133-9 (2000). Peters TG, Lewis JD, Wilkinson EJ, Fuhrman TM. Cancer. 40: 2797-800 (1977).

Physical State :
Solid
Solubility :
Soluble in water (partly), chloroform (25 mg/ml), acetone, acetonitrile, and ethanol.
Storage :
Store at room temperature
Melting Point :
225° C
Boiling Point :
478.19° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D 24.2°, c = 0.5 in chloroform
IC50 :
AR: IC50 = 12 nM (rat); PR: IC50 = 259 nM (bovine); CYP2C9: IC50 = 300 nM (human); PDE3: IC50 = 2.54 µM; Sodium Channel, Site 2 radioligand binding: IC50 = 2.98 µM
Ki Data :
AR: Ki= 7.99 nM (rat); PR: Ki= 34 nM (bovine); GR: Ki= 1.96 µM (human); SR-2A: Ki= 2.53 µM (human); Sodium Channel, Site 2 radioligand binding: Ki= 2.67 µM
pK Values :
pKa: 13.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TU4157070
PubChem CID :
28417
Merck Index :
14: 2812
MDL Number :
MFCD00056838
EC Number :
241-270-1
Beilstein Registry :
4851114
SMILES :
CC12CCC3C(CCC4=CC5=C(CC34C)C=NO5)C1CC[C@@]2(O)C#C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Danazol  Product Citations

See how others have used Danazol. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25811655  2015. PLoS ONE. 10: e0121316.

PMID: # 23089292  2012. Eur J Pharm Sci. 47: 842-7.

PMID: # 12042260  Ota H et al. 2002. Hum Reprod. 17(6): 1453-1458.

Citations 1 to 3 of 3 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 95ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 31ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.