DanazolA modified testosterone gonadotropin inhibitor

Danazol (CAS 17230-88-5)

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Application: A modified testosterone gonadotropin inhibitor
CAS Number: 17230-88-5
Purity: ≥98%
Molecular Weight: 337.46
Molecular Formula: C22H27NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats.


Niwa K, Hashimoto M, Morishita S, Yokoyama Y, Lian Z, Tagami K, Mori H, Tamaya T. Cancer Lett. 158:133-9 (2000). Peters TG, Lewis JD, Wilkinson EJ, Fuhrman TM. Cancer. 40: 2797-800 (1977).

Physical State :
Solubility :
Soluble in water (partly), chloroform (25 mg/ml), acetone, acetonitrile, and ethanol.
Storage :
Store at room temperature
Melting Point :
225° C
Boiling Point :
478.19° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D 24.2°, c = 0.5 in chloroform
IC50 :
AR: IC50 = 12 nM (rat); PR: IC50 = 259 nM (bovine); CYP2C9: IC50 = 300 nM (human); PDE3: IC50 = 2.54 µM; Sodium Channel, Site 2 radioligand binding: IC50 = 2.98 µM
Ki Data :
AR: Ki= 7.99 nM (rat); PR: Ki= 34 nM (bovine); GR: Ki= 1.96 µM (human); SR-2A: Ki= 2.53 µM (human); Sodium Channel, Site 2 radioligand binding: Ki= 2.67 µM
pK Values :
pKa: 13.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 2812
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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Danazol  Product Citations

See how others have used Danazol. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25811655  2015. PLoS ONE. 10: e0121316.

PMID: # 23089292  2012. Eur J Pharm Sci. 47: 842-7.

PMID: # 12042260  Ota H et al. 2002. Hum Reprod. 17(6): 1453-1458.

Citations 1 to 3 of 3 total
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