D609 CAS: 83373-60-8
MF: C11H15OS2K
MW: 266.46

D609 (CAS 83373-60-8)

D609 | CAS 83373-60-8 is rated 5.0 out of 5 by 1.
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Alternate Names: D609 is also known as Tricyclodecane-9-yl xanthate.
Application: D609 is a selective inhibitor of phosphatidylcholine-specific PLC, used to establish the functional coupling of PC-PLC with sphingomyelinase.
CAS Number: 83373-60-8
Purity: ≥98%
Molecular Weight: 266.46
Molecular Formula: C11H15OS2K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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D609 is a selective inhibitor of phosphatidylcholine-specific PLC (PC-PLC). D609 has been employed to establish the functional coupling of PC-PLC with sphingomyelinase and to establish the coupling of PC hydrolysis to the activation of Raf-1 protein kinase. A recent report showed that D609 indirectly inhibits phorbol ester-stimulated PLD activity. D609 possesses antitumor and antiviral activity. D609 also inhibits hypoxia-induced HIF-1α expression via blocking the biosynthesis of phosphatidic acid. D609 has provided benefits after stoke through induction of cell-cycle arrest by up-regulating p21, inhibition of SMS, causing hypophosphorylation of Rb and increased ceramide levels.


References

1. Keszthelyi, G. 1979. Fogorv Sz. 72(2): 56-61. PMID: 283935
2. Sauer, G. 1984. Proc. Natl. Acad. Sci. U.S.A. 81(11): 3263-3267. PMID: 6328507
3. Müller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162(1): 198-205. PMID: 2751648
4. Schütze, S. 1992. Cell. 71(5): 765-776. PMID: 1330325
5. Tschaikowsky, K. 1994. Br. J. Pharmacol. 113(3): 664-668. PMID: 7532078
6. Haralabopoulos, G.C. 1994. Lab. Invest. 71(4): 575-582. PMID: 7526036
7. Pörn-Ares, M.I. 1997. Exp. Cell Res. 235(1): 48-54. PMID: 9281351
8. Hooper, D.C. 1997. Proc. Natl. Acad. Sci. U.S.A. 94(6): 2528-2533. PMID: 9122229
9. Kiss, Z. 1998. Biochem. Pharmacol. 55(6): 915-918. PMID: 9586966
10. Kahle, P.J. 1998. Cell. Signal. 10(5): 321-330. PMID: 9692675
11. Kim, J.G. 2001. Exp. Mol. Med. 33(4): 303-309. PMID: 11795496
12. Adibhatla, R.M. 2010. Mol Neurobiol. PMID: 20148315

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), DMSO, and ethanol.
Storage :
Store at -20° C
IC50 :
PC-PLC: IC50 = 94 µm; LPS- and IFNγ-induced NO production : IC50 = 20 mg/ml; Cruzipain: IC50 = 15 µm (Trypanosoma cruzi); beta-lactamase AmpC: IC50 = 270 µm; Saccharomyces cerevisiae: EC5050 = 0.412 µm (Saccharomyces cerevisiae)
Ki Data :
PC-PLC: Ki= 6.4 µm; pc-specificphopholipase c: Ki= 5-10 µm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00171401
EC Number :
280-379-9
SMILES :
C1CC2C(C1)C3CC2CC3OC(=S)[S-].[K+]

Download SDS (MSDS)

Certificate of Analysis

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D609 (CAS 83373-60-8)  Product Citations

See how others have used D609 (CAS 83373-60-8). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 30370560  Fujihara, C.|Kanai, Y.|Masumoto, R.|Kitagaki, J.|Matsumoto, M.|Yamada, S.|Kajikawa, T.|Murakami, S.| et al. 2019. J. Cell. Physiol. 234: 7149-7160.

PMID: # 26650179  Suzuki, M. et al. 2016. J. Clin. Invest. 126: 254-65.

PMID: # 32938759  J. Virol.

PMID: # 29420297  J Cell Sci.

PMID: # 32223893  Elife. 9:

PMID: # 28176353  J Physiol. 2681-2698.

PMID: # 32636343  Plant Physiol.

Citations 1 to 7 of 7 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. D609, sc-201403, is a light yellow to yellow solid.
Answered by: Chemical Support 4
Date published: 2018-03-22

Is this compound cell permeable? Do we have any information about what concentration it should be used at?

Asked by: Jz28sail
Thank you for your question. sc-201403, D609 is not cell permeable. D609 has been shown to selectively inhibit phosphatidylcholine (PC)-specific phospholipase C at a 5 - 10 µM concentration.
Answered by: Chemical Support 5
Date published: 2017-11-26
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Rated 5 out of 5 by from Zapata Zapata-Martinez, et al. (PubMed ID 26350822) used D609 to inhibit PC-PLC in Rhinella arenarum oocytes. -SCBT Publication Review
Date published: 2015-07-07
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