D-NMAPPDD-NMAPPD is a potent Acid Ceramidase inhibitor that induces apoptosis.

D-NMAPPD (CAS 35922-06-6)

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Synonym: N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide; (1R,2R)-B13
Application: D-NMAPPD is a potent Acid Ceramidase inhibitor that induces apoptosis.
CAS Number: 35922-06-6
Molecular Weight: 422.56
Molecular Formula: C23H38N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-NMAPPD is an Acid Ceramidase (ceramidase) inhibitor, which acts to keep ceramide concentrations low and maintain cell viability in normal cells. The inhibition of Acid Ceramidase (ceramidase) in both non-cancerous and malignant cells leads to apoptosis. D-NMAPPD is a potent Acid Ceramidase (ceramidase) inhibitor that induces apoptosis.


References

1 Geley, S., Hartmann, B.L., Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 400 15-18 (1997). 2 Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1) 3-8 (2002). 3 Raisova, M., Goltz, G., Bektas, M., et al. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett 516 47-52 (2002). 4 Selzner, M., Bielawska, A., Morse, M.A., et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 61 1233-1240 (2001).

Physical State :
Solid
Solubility :
Soluble in water (0.3 mg/mL at 25° C), ethanol (~20 mg/mL), DMSO (~10 mg/mL), DMF (~10 mg/mL), and Ethanol: PBS (pH 7.2) (1: 2) (~0.3 mg/mL).
Storage :
Store at -20° C
Melting Point :
261.57° C (Predicted)
Boiling Point :
~636.2° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
Acid Ceramidase: IC50 = 10 µM (human); MCF7: IC50 = 14 µM (human); neutral ceramidase: IC50 = 120 µM (human)
pK Values :
pKa: 12.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10070893
MDL Number :
MFCD08062172
SMILES :
CCCCCCCCCCCCCC(=O)N[C@H](CO)[C@@H](C1=CC=C(C=C1)[N+](=O)[O-])O

Download SDS (MSDS)

Certificate of Analysis

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