D-NMAPPD is an Acid Ceramidase (ceramidase) inhibitor, which acts to keep ceramide concentrations low and maintain cell viability in normal cells. The inhibition of Acid Ceramidase (ceramidase) in both non-cancerous and malignant cells leads to apoptosis. D-NMAPPD is a potent Acid Ceramidase (ceramidase) inhibitor that induces apoptosis.
1 Geley, S., Hartmann, B.L., Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 400 15-18 (1997). 2 Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1) 3-8 (2002). 3 Raisova, M., Goltz, G., Bektas, M., et al. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett 516 47-52 (2002). 4 Selzner, M., Bielawska, A., Morse, M.A., et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 61 1233-1240 (2001).
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