D-myo-Inositol-1,4,5-trisphosphate hexasodium saltCAS: 108340-81-4
MF: C6H9O15P3•6Na
MW: 551.99
A Ca2+ mobilizing secondary messenger.

D-myo-Inositol-1,4,5-trisphosphate hexasodium salt (CAS 108340-81-4)

D-myo-Inositol-1,4,5-trisphosphate hexasodium salt | CAS 108340-81-4 is rated 5.0 out of 5 by 1.
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Application: A Ca2+ mobilizing secondary messenger
CAS Number: 108340-81-4
Purity: ≥98%
Molecular Weight: 551.99
Molecular Formula: C6H9O15P36Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-myo-Inositol-1,4,5-trisphosphate hexasodium salt is a secondary messenger molecule released as a product of polyphosphoinositide metabolism. IP3 is described to bind the Inositol-1,4,5-trisphosphate receptor (InsP3) and stimulate the mobilization of internal Ca2+ stores, generating local and global Ca2+ signals which regulate a range of cell processes.


References

1. Majerus, P.W., et al. 1986. Science. 234: 1519-1526. PMID: 3024320

2. Berridge, M.J. and Irvine, R.F. 1989. Nature. 341: 197-205. PMID: 2550825

3. Nahorski, S.R. and Potter, B.V. 1989. Trends Pharmacol. Sci. 10: 139-144. PMID: 2546303

4. Ferris, C.D., et al 1992. Adv. Second Messenger Phosphoprotein Res. 26: 95-107. PMID: 1329896

5. Foskett, J.K., et al. 2007. Physiol. Rev. 87: 593-658. PMID: 17429043

6. Jung, J.Y. et al. 2012. Chem. Commun. (Camb.). 48(64): 7928-7930. PMID: 22763433

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53229984
MDL Number :
MFCD00055051
SMILES :
[[email protected]]1([[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]([[email protected]@H]1OP(=O)([O-])[O-])O)OP(=O)([O-])[O-])OP(=O)([O-])[O-])O)O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

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Certificate of Analysis

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Rated 5 out of 5 by from Jung Jung, JY. et al. (PubMed 22763433) presented the first example of an imidazolium-based fluorescent receptor for D-myo-Inositol-1,4,5-trisphosphate (Ins(1,4,5)P3 . 6Na; IP3), a Ca2+ mobilizing secondary messenger. -SCBT Publication Review
Date published: 2015-03-08
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