D-myo-Inositol 1,4,5-trisphosphate (caged) trisodium saltMF: C14H19NO17P3•3Na
MW: 635.19
A photolabile Ins (1,4,5)P3 derivative.

D-myo-Inositol 1,4,5-trisphosphate (caged) trisodium salt

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Synonym: Ins(1,4,5)P3 (caged)•3Na
Application: A photolabile Ins (1,4,5)P3 derivative
Molecular Weight: 635.19
Molecular Formula: C14H19NO17P33Na
* Refer to Certificate of Analysis for lot specific data (including water content).

D-myo-Inositol 1,4,5-trisphosphate (caged), trisodium salt, is a photolabile Ins(1,4,5)P3 derivative with a cage on position 4, which does not show biological activity until photochemical destruction of the cage. A short light pulse (254 or 360nm) releases active Ins(1,4,5)P3 within a second, thus mimicking the rapid responses of the receptor/phospholipase C signalling system in the cell. Since this approach does not (directly) trigger other signaling events, such as protein kinase C (PKC) activation after receptor-mediated diacylglycerol (DAG) formation, this provides a tool for dissecting signaling pathways. D-myo-Inositol 1,4,5-trisphosphate (caged), trisodium salt, is not metabolized by endogenous phosphatase.


1. Walker, J W., et al., . Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate. Nature. 327(6119): 249-52. PMID: 3494954

Appearance :
Physical State :
Solubility :
Soluble in water.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
[Na]OP(=O)(O[[email protected]@H]1[[email protected]@H](O)[[email protected]@H](O)[[email protected]@H](OP(=O)(O)O[Na])[[email protected]](O)[[email protected]]1OP(=O)(O)O[Na])OC(C)c1ccccc1[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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