D-myo-Inositol 1,4,5-trisphosphate (caged) trisodium saltA photolabile Ins (1,4,5)P3 derivative

D-myo-Inositol 1,4,5-trisphosphate (caged) trisodium salt

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 73ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Ins(1,4,5)P3 (caged)•3Na
Application: A photolabile Ins (1,4,5)P3 derivative
Molecular Weight: 635.19
Molecular Formula: C14H19NO17P33Na
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

D-myo-Inositol 1,4,5-trisphosphate (caged), trisodium salt, is a photolabile Ins(1,4,5)P3 derivative with a cage on position 4, which does not show biological activity until photochemical destruction of the cage. A short light pulse (254 or 360nm) releases active Ins(1,4,5)P3 within a second, thus mimicking the rapid responses of the receptor/phospholipase C signalling system in the cell. Since this approach does not (directly) trigger other signaling events, such as protein kinase C (PKC) activation after receptor-mediated diacylglycerol (DAG) formation, this provides a tool for dissecting signaling pathways. D-myo-Inositol 1,4,5-trisphosphate (caged), trisodium salt, is not metabolized by endogenous phosphatase.


References

1. Walker, J W., et al., . Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate. Nature. 327(6119): 249-52. PMID: 3494954

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57347474
MDL Number :
MFCD08062301
SMILES :
[Na]OP(=O)(O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](OP(=O)(O)O[Na])[C@H](O)[C@H]1OP(=O)(O)O[Na])OC(C)c1ccccc1[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 63ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 34ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.