D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) is formed by the phosphorylation of Ins(1,4,5)P4 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 augments intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell.
1 Billington, D.C., Baker, R., Kulagowski, J.J., et al. Synthesis of myo-inositol 1-phosphate and 4-phosphate, and their individual enantiomers. J Chem Soc , Chem Commun (1987). 2 Communi, D., Vanweyenberg, V., Erneux, C. Purification and biochemical properties of a high-molecular-mass inositol 1,4,5-trisphosphate 3-kinase isoenzyme in human platelets. Biochem J 298 669-673 (1994). 3 Lückhoff, A., Clapham, D.E. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel. Nature 355 356-358 (1992).
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