D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)A compound that affects calcium channels

D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) (CAS 210488-61-2)

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Synonym: 1,3,4,5-IP4; Ins(1,3,4,5)-P4
Application: A compound that affects calcium channels
CAS Number: 210488-61-2
Molecular Weight: 675.9
Molecular Formula: C6H8O18P48Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) is formed by the phosphorylation of Ins(1,4,5)P4 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 augments intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell.


References

1 Billington, D.C., Baker, R., Kulagowski, J.J., et al. Synthesis of myo-inositol 1-phosphate and 4-phosphate, and their individual enantiomers. J Chem Soc , Chem Commun (1987). 2 Communi, D., Vanweyenberg, V., Erneux, C. Purification and biochemical properties of a high-molecular-mass inositol 1,4,5-trisphosphate 3-kinase isoenzyme in human platelets. Biochem J 298 669-673 (1994). 3 Lückhoff, A., Clapham, D.E. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel. Nature 355 356-358 (1992).

Appearance :
Lyophilized powder
Physical State :
Solid
Solubility :
Soluble in PBS (pH 7.2) (~50 mg/ml), ethanol (sparingly), DMSO (sparingly), and DMF (sparingly).
Storage :
Store at -20° C
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
IP3R-III: IC50 = 2.9 nM (human); Inositol-trisphosphate 3-kinase A: IC50 = 27.8 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD00153818
SMILES :
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O[C@@H]1[C@H](OP(=O)([O-])[O-])[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)([O-])[O-])[C@@H](O)[C@@H]1OP(=O)([O-])[O-]

Download SDS (MSDS)

Certificate of Analysis

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