D-myo-Inositol 1,3,4,5,6-pentakisphosphate pentapotassium salt (CAS 20298-95-7 free acid)
D-myo-Inositol 1,3,4,5,6-pentakisphosphate pentapotassium salt reduces the IP4 binding activity of Bruton's tyrosine kinase (Btk).
References
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation: L.R. Stephens, et al.; Biochem. J. 253, 721 (1988) Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brai: A. Höer & E. Oberdisse; Biochem. J. 278, 219 (1991) Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity: M. Fukuda, et al.; J. Biol. Chem. 271, 30303 (1996)
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PMID: # 24649396 Abe, TK. et al. 2014. FEBS Open Bio. 4: 162-7.
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