Molecular structure of D-(−)-Salicin, CAS Number: 138-52-3
D-(−)-Salicin (CAS 138-52-3)
Alternate Names:
2-(Hydroxymethyl)phenyl-β-D-glucopyranoside, Salicoside, Salicyl alcohol glucoside, Saligenin β-D-glucoside
Application:
D-(−)-Salicin is an inhibitor of Cox
CAS Number:
138-52-3
Purity:
99%
Molecular Weight:
286.28
Molecular Formula:
C13H18O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-(−)-Salicin is functions as an anti-inflammatory agent in experimental applications. It acts by inhibiting the production of prostaglandins, which are lipid compounds involved in inflammatory response. D-(−)-Salicin specifically targets the enzyme cyclooxygenase, reducing its activity and subsequently decreasing the synthesis of prostaglandins. By interfering with this specific molecular pathway, D-(−)-Salicin effectively modulates the inflammatory process at the cellular level.
D-(−)-Salicin (CAS 138-52-3) References
- Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. | Warner, TD., et al. 1999. Proc Natl Acad Sci U S A. 96: 7563-8. PMID: 10377455
- Relaxation behaviour of D(-)-salicin as studied by Thermally Stimulated Depolarisation Currents (TSDC) and Differential Scanning Calorimetry (DSC). | Diogo, HP., et al. 2008. Int J Pharm. 358: 192-7. PMID: 18417303
- Calorimetric studies on the phenolic glycoside D(-)-salicin. | Pinto, SS. and Diogo, HP. 2008. J Pharm Sci. 97: 5354-62. PMID: 18484613
- Application of high-performance liquid chromatography for research of salicin in bark of different varieties of Salix. | Kenstaviciene, P., et al. 2009. Medicina (Kaunas). 45: 644-51. PMID: 19773624
- Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. | Wooding, S., et al. 2010. Chem Senses. 35: 685-92. PMID: 20551074
- Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception. | Behrens, M., et al. 2013. Chem Senses. 38: 475-84. PMID: 23632915
- D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models. | Li, Y., et al. 2015. Int Immunopharmacol. 26: 286-94. PMID: 25907238
- Miktoarm star copolymers from D-(-)-salicin core aggregated into dandelion-like structures as anticancer drug delivery systems: synthesis, self-assembly and drug release. | Mielańczyk, A., et al. 2016. Int J Pharm. 515: 515-526. PMID: 27771487
- Feasibility of Fraction Collection in HPLC Systems with Evaporative Light Scattering Detector: Analysis of Pectinatella magnifica. | Pazourek, J. and Šmejkal, K. 2016. Molecules. 21: PMID: 27834833
- Discovery of salicyl benzoate UDP-glycosyltransferase, a central enzyme in poplar salicinoid phenolic glycoside biosynthesis. | Fellenberg, C., et al. 2020. Plant J. 102: 99-115. PMID: 31736216
- A simple and portable method for β-Glucosidase activity assay and its inhibitor screening based on a personal glucose meter. | Chen, GY., et al. 2021. Anal Chim Acta. 1142: 19-27. PMID: 33280697
- D(-)-salicin inhibits RANKL-induced osteoclast differentiation and function in vitro. | Xiao, Y., et al. 2022. Fitoterapia. 157: 104981. PMID: 34182052
- A Paper-Based Analytical Device Integrated with Smartphone: Fluorescent and Colorimetric Dual-Mode Detection of β-Glucosidase Activity. | Zhang, WY., et al. 2022. Biosensors (Basel). 12: PMID: 36291030
Inhibitor of:
β3Gn-T4, C85492, Cox, Sucrase-Isomaltase, T2R14, T2R16, T2R48, and T2R9.Activator of:
β-glucosidase, Amyloglucosidase, T2R10, T2R21, T2R3, T2R31, T2R42, T2R43, T2R45, T2R47, T2R49, T2R50, T2R60, T2R7, T2R8, T2R9, Tas2r102, Tas2r140, and Tas2r143.Substrate of:
beta-glucosidase, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-(−)-Salicin, 5 g | sc-218004 | 5 g | $58.00 |