D-Mannose-6-phosphate, Disodium SaltCAS: 33068-18-7
MF: C6H11O9P•2Na
MW: 304.1
A targeting signal for lysosomal hydrolases.

D-Mannose-6-phosphate, Disodium Salt (CAS 33068-18-7)

D-Mannose-6-phosphate, Disodium Salt | CAS 33068-18-7 is rated 5.0 out of 5 by 1.
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Synonym: disodium (3,4,5,6-tetrahydroxytetrahydropyran-2-yl)methyl phosphate
Application: A targeting signal for lysosomal hydrolases
CAS Number: 33068-18-7
Purity: ≥98%
Molecular Weight: 304.1
Molecular Formula: C6H11O9P•2Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-Mannose-6-phosphate, Disodium Salt (M6P) is a molecule bound by lectin, which functions as a targeting signal for lysosomal hydrolases. The cells with M6P markers are recognized by specific receptors mediating their transport to an endosomal/prelysosomal compartment where they will be degraded by lysosomes. Furthermore, D-Mannose-6-phosphate can be converted into various isomers including, the isomer D-fructose 6-phosphate enzymatically using Mannose 6-phosphate isomerase.


References

1. Rom, W.N. 1991. Am. J. Respir. Cell Mol. Biol. 4: 555-559. PMID: 1647180
2. Gowda, G., et al. 2008. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 81-84. PMID: 18259054
3. Kollmann, K., et al. 2010. Eur. J. Cell Biol. 89: 117-123. PMID: 19945768
4. Chu, H.Y., et al. 2010. J Mol Model. [Epub ahead of print]. PMID: 20512605

Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
118026
MDL Number :
MFCD00135857
SMILES :
C(C1C(C(C(C(O1)O)O)O)O)OP(=O)([O-])[O-].[Na+].[Na+]

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Rated 5 out of 5 by from Chu Chu, HY. et al. (PubMed 20512605) investigated the reaction mechanism of the -phosphomannomutase1 enzyme by means of density functional theory using the hybrid functional B3LYP. They reported that the -phosphomannomutase1 catalyzes the interconversion of the -D-mannose 1-phosphate to D-Mannose-6-phosphate via a mannose-1,6-(bis) phosphate intermediate. -SCBT Publication Review
Date published: 2015-06-23
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