D-LimoneneActivates UGT and hepatic GST

D-Limonene (CAS 5989-27-5)

D-Limonene | CAS 5989-27-5 is rated 5.0 out of 5 by 1.
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Synonym: (+)-Dipentene; (R)-(+)-Limonene
Application: Activates UGT and hepatic GST
CAS Number: 5989-27-5
Purity: ≥96%
Molecular Weight: 136.23
Molecular Formula: C10H16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-Limonene is a monoterpene found to prevent mammary cancer by activating hepatic glutathione-S-transferase (GST) and uridine diphosphoglucuronosyl transferase (UGT). D-Limonene is an isoprenylation inhibitor of small G-proteins.


References

1. Elegbede, J A., et al., 1993. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. Carcinogenesis. 14(6): 1221-3. PMID: 8508509
2. Gould, M N., et al., 1997. Cancer chemoprevention and therapy by monoterpenes. Environmental health perspectives. 105 Suppl 4(): 977-9. PMID: 9255590

Physical State :
Liquid
Solubility :
Soluble in ethanol, carbon tetrachloride, and glycerin (slightly). Insoluble in water (0.02 mg/ml at 25° C), and propylene glycol.
Storage :
Store at room temperature
Melting Point :
-74° C (lit.)
Boiling Point :
176-177° C (lit.)
Density :
0.84 g/mL at 20° C (lit.)
Refractive Index :
n20D 1.47 (lit.)
Optical Activity :
α20/D +115°, c = 10 in ethanol; α20/D 100.5°±4.5°, c = neat; α20/D 106°±4°, c = 1 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
GW6360000
PubChem CID :
440917
Merck Index :
14: 5493
MDL Number :
MFCD00062991
EC Number :
227-813-5
Beilstein Registry :
2204754
SMILES :
CC1=CC[C@@H](CC1)C(=C)C

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Certificate of Analysis

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D-Limonene  Product Citations

See how others have used D-Limonene. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29191726  Bartoňková, I. et al. 2018. Food Chem. Toxicol. 111: 374-384.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Gould et al Gould et al. (PubMed ID 9255590) found that D-limonene to be an effective treatment for neuroblastomas and leukemias by inhibiting isoprenylation of small G proteins. -SCBT Publication Review
Date published: 2015-06-03
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