D,L-SulforaphaneAn inducer of phase II detoxification enzymes used for breast cancer research

D,L-Sulforaphane (CAS 4478-93-7)

D,L-Sulforaphane | CAS 4478-93-7 is rated 5.0 out of 5 by 1.
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Synonym: 1-Isothiocyanato-4-(methylsulfinyl)-butane
Application: An inducer of phase II detoxification enzymes used for breast cancer research
CAS Number: 4478-93-7
Purity: ≥95%
Molecular Weight: 177.29
Molecular Formula: C6H11NOS2
* Refer to Certificate of Analysis for lot specific data (including water content).
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D,L-Sulforaphane (SFN) is a potent and selective inducer of phase II detoxification enzymes with anticarcinogenic and anti-microbial properties. SFN acts as an antitumor agent that was found to inhibit chemically induced mammary tumor formation in rats. It increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. D,L-Sulforaphane is an inhibitor of Aryl Hydrocarbon Receptor. SFN regulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.


References

1. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 2399-2403. PMID: 1549603

2. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 3147-3150. PMID: 8159717

3. Hahm, E.R., et al. 2010. Cancer Prev Res. 3: 484-494. PMID: 20233902

4. Lars-Ove Brandenburg et. al
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(6), undefined (2009-11-20). PMID: 19924513

5. Han, D., Et al. 2011. Int. J. Mol .Sci. 12(3):.1854-1861.PMID: 21673926.

6. Yangfan P Liu et. al
The Journal of clinical investigation, 124(5), undefined (2014-4-3). PMID: 24691443

7. A Kenneth MacLeod et. al
British journal of cancer, 115(12), undefined (2016-11-9). PMID: 27824809

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in chloroform, dichloromethane, DMF (~3 mg/ml), and DMSO (40 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
68.93° C (Predicted)
Boiling Point :
125-135° C
Density :
~1.2 g/mL (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
ADMET: IC50 = 0.01 nM; Jurkat: IC50 = 3.8 µM (human); DU-145: IC50 = 10 µM (human); Trypanosoma cruzi: IC50 = 15 µM; HepG2: IC50 = 24.89 µM (human)
pK Values :
pKa: -4.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KQ6300000
PubChem CID :
5350
Merck Index :
14: 8962
MDL Number :
MFCD00198068
EC Number :
200-578-6
SMILES :
CS(=O)CCCCN=C=S

Download SDS (MSDS)

Certificate of Analysis

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D,L-Sulforaphane  Product Citations

See how others have used D,L-Sulforaphane. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27779894  Vanduchova, A. et al. 2016. J Med Food. 19: 1141-1146.

PMID: # 26082278  Aissani, N. et al. 2015. J. Agric. Food Chem. 63: 6120-5.

PMID: # 24975513  Bricker, GV. et al. 2014. Mol Nutr Food Res. 58: 1991-2000.

PMID: # 21949655  Olagnier, D. et al. 2011. PLoS pathogens. 7: e1002254.

Citations 1 to 4 of 4 total

What is the maximum absorbance wavelength of D,L Sulforaphane ??

Asked by: vinaynit21
Thank you for your question. We have not tested the maximum absorbance wavelength of D,L Sulforaphane. According to the below journal article, Sulforaphane displayed the largest absorbance under 205 nm. Han, D., Et al. 2011. Int. J. Mol .Sci. 12(3):.1854-1861.PMID: 21673926
Answered by: Technical Support
Date published: 2019-09-11

I was wondering what solvents can be used to dissolve this product?

Asked by: 13punMA
Thank you for asking about our D,L-Sulforaphane (CAS# 4478-93-7). The recommended solvents for the product is Chloroform, Dichloromethane, or Diethyl Ether.
Answered by: Chemical Support 8
Date published: 2017-03-10

I was wondering if there are any special instructions for storing the product to keep it stable for long periods.

Asked by: 13punMA
Thank you for asking about our D,L-Sulforaphane (CAS# 4478-93-7). For long term storage, the product should be dissolved in Chloroform, Dichloromethane or Diethyl Ether at -20 ºC. Otherwise the product would be best if made fresh.
Answered by: Chemical Support 8
Date published: 2017-03-10

Is the appearance of this compound, it's native form? If not, what is the liquid it is stored in?

Asked by: 13punMA
Hello, thank you for asking about our product D,L-Sulforaphane (CAS# 4478-93-7) The product comes in its pure form and is not dissolved in anything at all.
Answered by: Chemical Support 8
Date published: 2017-03-01
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Rated 5 out of 5 by from SF (5 M; 4 h) treatment was included as SF (5 M; 4 h) treatment was included as a positive control - published western blot data. -SCBT Publication Review
Date published: 2015-07-27
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