D,L N,O-Didesmethyl VenlafaxineA metabolite of the reuptake inhibitor Venlafaxine

D,L N,O-Didesmethyl Venlafaxine (CAS 135308-74-6)

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Application: A metabolite of the reuptake inhibitor Venlafaxine
CAS Number: 135308-74-6
Molecular Weight: 249.35
Molecular Formula: C15H23NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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D,L N,O-Didesmethyl Venlafaxine is a metabolite of Venlafaxine (sc-201102). Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake. In vitro studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.


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Physical State :
Solubility :
Soluble in Dimethyl Sulfoxide, Ethyl Acetate, and Methanol
Storage :
Store at -20° C
Melting Point :
174-175°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Certificate of Analysis

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