D,L-Buthionine-(S,R)-sulfoximine is a potent and specific α-glutamyl cysteine synthetase inhibitor, as well as an inhibitor of γ-GCSc. D,L-Buthionine-(S,R)-sulfoximine activity can lead to the inhibition of the proliferative response in human T-lymphocytes and inhibition of macrophage activation.
Griffith, O.W., et al.: J. Biol. Chem., 254, 16, 7558 (1979), Griffith, O.W., et al.: Methods Enzymol., 77, 59 (1981),
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