(D) DT-2A potent, cell permeable and highly selective polypeptide inhibitor of cGMP dependent protein kinase 1α

(D) DT-2

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Synonym: PKG Inhibitor Peptide, YGRKKRRQRRRPPLRKKKKKH-NH2 (all-d)
Application: A potent, cell permeable and highly selective polypeptide inhibitor of cGMP dependent protein kinase 1α
Molecular Weight: 2800.5 (free peptide)
Molecular Formula: C122H223N53O23 (free peptide)
* Refer to Certificate of Analysis for lot specific data (including water content).

(D) DT-2 is a potent, cell permeable and highly selective polypeptide inhibitor of cGKI α (cGMP dependent protein kinase 1α) (Ki = 0.8 nM) and cGKI β. This compound has shown approximately 15,000 fold selectivity for PKG-1α over other cAMP-dependent protein kinases, and is composed of D-amino acids which helps resist proteolysis.


References

1. Nickl, C.K. et al. 2010. Biochim. Biophys. Acta. 1804(3): 524-532. PMID: 20018259

Appearance :
Powder
Physical State :
Solid
Sequence :
YGRKKRRQRRRPPLRKKKKKH-NH2 (all-d)
Solubility :
Soluble in water (≥6 mM).
Storage :
Store at -20° C
Ki Data :
cGMP dependent protein kinase 1α: Ki= 0.8 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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