(D) DT-2 is a potent, cell permeable and highly selective polypeptide inhibitor of cGKI α (cGMP dependent protein kinase 1α) (Ki = 0.8 nM) and cGKI β. This compound has shown approximately 15,000 fold selectivity for PKG-1α over other cAMP-dependent protein kinases, and is composed of D-amino acids which helps resist proteolysis.
1. Nickl, C.K. et al. 2010. Biochim. Biophys. Acta. 1804(3): 524-532. PMID: 20018259
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