D-α-Tocopheryl Succinate is a potent antioxidant tocopherol. At high concentrations it has been shown to trigger caspase-mediated apoptosis of certain cells and, at low concentrations, inhibit proliferation. Mechanistic studies suggest that this compound down-regulates the fibroblast growth factor receptor-1 (FGFR1). Other experiments report that D-α-Tocopheryl Succinate also targets ASK 1, GADD 45β, and MEK-4, three key components of stress-activated mitogen-activated protein kinase pathway.
1. Wu, K., et al. 2002. World J. Gastroenterol. 8: 26-30. PMID: 11833065 2. Stapelberg, M., et al. 2004. Biochem. Biophys. Res. Commun. 318: 636-641. PMID: 15144885 3. Neuzil, J., et al. 2004. Curr Cancer Drug Targets. 4: 355-372. PMID: 15180501 4. Zu, K., et al. 2005. Mol. Cancer Ther. 4: 43-50. PMID: 15657352
Soluble in DMSO, chloroform (50 mg/ml), and ethanol. Insoluble in water.
Rated 5 out of
ZuZu, K. et al. (PubMed 15657352) reported that up-regulation of c-Jun-NH2-kinase pathway contributed to the induction of mitochondria-mediated apoptosis by D- -Tocopheryl Succinate in human prostate cancer cells. -SCBT Publication Review
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