D-α-Tocopheryl SuccinateA potent antioxidant tocopherol

D-α-Tocopheryl Succinate (CAS 4345-03-3)

D-α-Tocopheryl Succinate, CAS 4345-03-3 is rated 5.0 out of 5 by 1.
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Application: A potent antioxidant tocopherol
CAS Number: 4345-03-3
Purity: ≥98%
Molecular Weight: 530.80
Molecular Formula: C33H54O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-α-Tocopheryl Succinate is a potent antioxidant tocopherol. At high concentrations it has been shown to trigger caspase-mediated apoptosis of certain cells and, at low concentrations, inhibit proliferation. Mechanistic studies suggest that this compound down-regulates the fibroblast growth factor receptor-1 (FGFR1). Other experiments report that D-α-Tocopheryl Succinate also targets ASK 1, GADD 45β, and MEK-4, three key components of stress-activated mitogen-activated protein kinase pathway.


References

1. Wu, K., et al. 2002. World J. Gastroenterol. 8: 26-30. PMID: 11833065
2. Stapelberg, M., et al. 2004. Biochem. Biophys. Res. Commun. 318: 636-641. PMID: 15144885
3. Neuzil, J., et al. 2004. Curr Cancer Drug Targets. 4: 355-372. PMID: 15180501
4. Zu, K., et al. 2005. Mol. Cancer Ther. 4: 43-50. PMID: 15657352

Physical State :
Solid
Solubility :
Soluble in DMSO, chloroform (50 mg/ml), and ethanol. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
75° C
Boiling Point :
~625.8° C at 760 mmHg (Predicted)
Density :
~1.00 g/cm3 (Predicted)
Refractive Index :
n20D 1.50
IC50 :
4T1 (Mammary carcinoma cells): IC50 = 10000 nM (mouse); MCF7 (Breast carcinoma cells): IC50 = >368000 nM (human)
Fluoresence :
λex 290 nm, λem 330 nm
pK Values :
pKa: 4.35
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
EJ9984000
PubChem CID :
20353
Merck Index :
14: 9495
MDL Number :
MFCD00072055
EC Number :
224-403-8
Beilstein Registry :
4038233
SMILES :
CC1=C2C(=C(C(=C1C)OC(=O)CCC(=O)O)C)CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied in white granules or a crystalline powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-18
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Rated 5 out of 5 by from Zu Zu, K. et al. (PubMed 15657352) reported that up-regulation of c-Jun-NH2-kinase pathway contributed to the induction of mitochondria-mediated apoptosis by D- -Tocopheryl Succinate in human prostate cancer cells. -SCBT Publication Review
Date published: 2015-03-05
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