Cytochalasin J is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin J is the deacetyl analogue of cytochalasin H (sc-202119) and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumor activities.
1. Cooper, J.A. 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229 2. Snyder, J.A. and Cohen, L. 1995. Cell Motil. Cytoskeleton. 32: 245-257. PMID: 8608604 3. Wrench, G.A. and Snyder, J.A. 2001. Cell Biol. Int. 25: 815-820. PMID: 11482906 4. Robinson, R.W. and Snyder, J.A. 2003. Cell Biol. Int. 27: 665-673. PMID: 12867158
Cytochalasins are regarded as highly toxic and possible teratogens. Handle in a manner to avoid/minimize direct body contact and inhalation.
Soluble in ethanol, methanol, DMF, DMSO, and water (poorly).
Store at -20° C
679.51° C at 760 mmHg (Predicted)
1.20 g/cm3 (Predicted)
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
ChoiChoi, BH. et al. (PubMed 15800051) found that pretreatment of Ltk- cells with Cytochalasin J and an actin filament stabilizing agent phalloidin, had no effect on the cytochalasin B-induced inhibition of hKv1.5 currents. -SCBT Publication Review
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