Cytochalasin JA cell-permeable fungal toxin used in actin polymerization studies and cytological research

Cytochalasin J (CAS 53760-20-6)

Cytochalasin J | CAS 53760-20-6 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable fungal toxin used in actin polymerization studies and cytological research
CAS Number: 53760-20-6
Purity: >95%
Molecular Weight: 451.6
Molecular Formula: C28H37NO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cytochalasin J is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin J is the deacetyl analogue of cytochalasin H (sc-202119) and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumor activities.


References

1. Cooper, J.A. 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229
2. Snyder, J.A. and Cohen, L. 1995. Cell Motil. Cytoskeleton. 32: 245-257. PMID: 8608604
3. Wrench, G.A. and Snyder, J.A. 2001. Cell Biol. Int. 25: 815-820. PMID: 11482906
4. Robinson, R.W. and Snyder, J.A. 2003. Cell Biol. Int. 27: 665-673. PMID: 12867158

Usage :
Cytochalasins are regarded as highly toxic and possible teratogens. Handle in a manner to avoid/minimize direct body contact and inhalation.
Physical State :
Solid
Derived From :
Phomopsis sp.
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (poorly).
Storage :
Store at -20° C
Melting Point :
137-139° C
Boiling Point :
679.51° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
45051831
MDL Number :
MFCD00077708
SMILES :
CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1)(C)O)O)C(=O)NC3CC4=CC=CC=C4)C)O

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Certificate of Analysis

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Cytochalasin J  Product Citations

See how others have used Cytochalasin J. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 15800051  Choi, BH. et al. 2005. Am. J. Physiol., Cell Physiol. 289: C425-C436.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Choi Choi, BH. et al. (PubMed 15800051) found that pretreatment of Ltk- cells with Cytochalasin J and an actin filament stabilizing agent phalloidin, had no effect on the cytochalasin B-induced inhibition of hKv1.5 currents. -SCBT Publication Review
Date published: 2015-01-30
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