Cytochalasin E, Aspergillus clavatus CAS: 36011-19-5
MF: C28H33NO7
MW: 495.56
A fungal toxin used in actin polymerization and cytological research.

Cytochalasin E, Aspergillus clavatus (CAS 36011-19-5)

Cytochalasin E, Aspergillus clavatus | CAS 36011-19-5 is rated 5.0 out of 5 by 1.
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Application: Cytochalasin E, Aspergillus clavatus is a fungal toxin used in actin polymerization and cytological research
CAS Number: 36011-19-5
Purity: >98%
Molecular Weight: 495.56
Molecular Formula: C28H33NO7
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cytochalasin E, Aspergillus clavatus is used in actin polymerization studies. Cytochalasin E is a metabolite of the fungus Aspergillus clavatus which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. The class of Cytochalasin fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. As opposed to Cytochalasins A and B (sc-204705; sc-3519), Cytochalasin E does not inhibit monosaccharide transport across the plasma membrane.
Other Cytochalasins available: Cytochalasin C (sc-202118); Cytochalasin D (sc-201442); Cytochalasin H (sc-202119); Cytochalasin J (sc-202120)


References

1. Lin, D.C. and Lin, S. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 2345-2349. PMID: 287078
2. Flanagan, M.D. and Lin, S. 1980. J. Biol. Chem. 255: 835-838. PMID: 7356663
3. Fox, J.E. and Phillips, D.R. 1981. Nature. 292: 650-652. PMID: 6894786
4. Mookerjee, B.K., et al. 1984. J Immunopharmacol. 6: 185-203. PMID: 6491312
5. Cooper, J.A. 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229

Usage :
Cytochalasin A, C, D and E should be stored in the dark to prevent trans to cis isomerization of the conjugated double bond present in these forms.

Cytochalasins are regarded as highly toxic and possible teratogens. Handle in a manner to avoid/minimize direct body contact and inhalation.
Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), EtOAc, ethyl acetatea (5 mg/ml), ethanol, methanol, DMF, chloroform, acetone, dichloromethane, and water (sparingly).
Storage :
Store at -20° C
Melting Point :
206.05° C (dec.)
Boiling Point :
705.06° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α25/D -25.6° in methanol
IC50 :
HUVEC50: IC50 = 11.4 nM (human); A549: IC50 = 6.2 nM (human)
pK Values :
pKa: 11.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HA5360000
PubChem CID :
Merck Index :
14: 2790
MDL Number :
MFCD00005178
EC Number :
252-835-7
Beilstein Registry :
1096975

Download SDS (MSDS)

Certificate of Analysis

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Cytochalasin E, Aspergillus clavatus (CAS 36011-19-5)  Product Citations

See how others have used Cytochalasin E, Aspergillus clavatus (CAS 36011-19-5). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 9834000  Gan, Y. et al. 1998. Pharm. Res. 15: 1760-1766.

PMID: # 9105920  Lopez-Diaz, TM. et al. 1997. Int. J. Food Microbiol. 35: 129-136.

PMID: # 6954540  Pessin, JE. et al. 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 2286-2290.

PMID: # 7200980  Shanahan, MF. et al. 1982. J. Biol. Chem. 257: 7290-7293.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Various publications cite the use of Cytochalasin Various publications cite the use of Cytochalasin E (Aspergillus clavatus) as a common tool in cytological research. It is used in actin polymerization studies because of its ability to bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation subunits. -SCBT Publication Review
Date published: 2015-01-11
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