Cytochalasin C is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin C has shown to be 10 times less toxic in mice than cytochalasin D (sc-201442), but with essentially the same biological effectiveness against cells in culture. Other Cytochalasins available: Cytochalasin A (sc-204705); cytochalasin B (sc-3519); Cytochalasin E, Aspergillus clavatus (sc-202561); Cytochalasin H (sc-202119); Cytochalasin J (sc-202120)
1. Carter, S.B. 1967. Nature. 213: 261-264. PMID: 6067685 2. Carter, S.B. 1972. Endeavour. 31: 77-82. PMID: 4113813 3. Yahara, I., et al. 1982. J. Cell Biol. 92: 69-78. PMID: 7199054 4. Cooper, J.A. 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229 5. Walling, E.A., et al. 1988. Arch. Biochem. Biophys. 264: 321-332. PMID: 3395126 6. Varedi, M., et al. 1995. J. Invest. Dermatol. 104: 118-123. PMID: 7528243
Cytochalasin A, C, D and E should be stored in the dark to prevent trans to cis isomerization of the conjugated double bond present in these forms.
Soluble in DMSO, 100% ethanol, and dichloromethane. Insoluble in water.
Store at -20° C
260-266.1° C (dec.)
714.32° C at 760 mmHg (Predicted)
n20D 1.60 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
OttonelloOttonello, L. et al. (PubMed 14534155) preincubated neutrophils with Cytochalasin C, a fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits, for a superoxide anion release assay. -SCBT Publication Review
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