Cytochalasin CA cell-permeable fungal toxin used in actin polymerization studies and cytological research

Cytochalasin C (CAS 22144-76-9)

Cytochalasin C | CAS 22144-76-9 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable fungal toxin used in actin polymerization studies and cytological research
CAS Number: 22144-76-9
Purity: >99%
Molecular Weight: 507.6
Molecular Formula: C30H37NO6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cytochalasin C is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin C has shown to be 10 times less toxic in mice than cytochalasin D (sc-201442), but with essentially the same biological effectiveness against cells in culture.
Other Cytochalasins available: Cytochalasin A (sc-204705); cytochalasin B (sc-3519); Cytochalasin E, Aspergillus clavatus (sc-202561); Cytochalasin H (sc-202119); Cytochalasin J (sc-202120)


References

1. Carter, S.B. 1967. Nature. 213: 261-264. PMID: 6067685
2. Carter, S.B. 1972. Endeavour. 31: 77-82. PMID: 4113813
3. Yahara, I., et al. 1982. J. Cell Biol. 92: 69-78. PMID: 7199054
4. Cooper, J.A. 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229
5. Walling, E.A., et al. 1988. Arch. Biochem. Biophys. 264: 321-332. PMID: 3395126
6. Varedi, M., et al. 1995. J. Invest. Dermatol. 104: 118-123. PMID: 7528243

Usage :
Cytochalasin A, C, D and E should be stored in the dark to prevent trans to cis isomerization of the conjugated double bond present in these forms.
Appearance :
Powder
Physical State :
Solid
Derived From :
Geniculosporium sp.
Solubility :
Soluble in DMSO, 100% ethanol, and dichloromethane. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
260-266.1° C (dec.)
Boiling Point :
714.32° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3
Refractive Index :
n20D 1.60 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HA5300500
PubChem CID :
16211913
Merck Index :
14: 2790
MDL Number :
MFCD00066080
EC Number :
244-803-6
Beilstein Registry :
1613194
SMILES :
CC1CC=CC2C(C(=C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)C)O

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Certificate of Analysis

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Cytochalasin C  Product Citations

See how others have used Cytochalasin C. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 15085540  Konur, S. et al. 2004. J. Neurobiol. 59: 236-246.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Ottonello Ottonello, L. et al. (PubMed 14534155) preincubated neutrophils with Cytochalasin C, a fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits, for a superoxide anion release assay. -SCBT Publication Review
Date published: 2015-06-01
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