Cytidine 5prime-diphosphocholine, Sodium Salt (CDP-choline)CAS: 33818-15-4
MF: C14H25N4O11P2•Na
MW: 510.31
A PLA2 inhibitor and acetylcholine receptor inducer.

Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline) (CAS 33818-15-4)

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Synonym: Citicoline Sodium
Application: A PLA2 inhibitor and acetylcholine receptor inducer
CAS Number: 33818-15-4
Purity: ≥98%
Molecular Weight: 510.31
Molecular Formula: C14H25N4O11P2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cytidine 5'-diphosphocholine (CDP-choline) is a naturally occurring precurser of phosphatidylcholine that has been shown to prevent post-necrotic lesion phospholipid destruction by inhibiting activation of phopholipase A2 (PLA2) at 200 mg/kg. CDP-choline has been shown to induce dopamine and acetylcholine receptor densities. Other studies have shown neural and non-neural cholinergic activity increase. Additionally CDP-choline has been noted to potentially increase the stimulated release of thyroid stimulating hormone, growth hormone, and luteinizing hormone.


References

1. Arrigoni, E., et al. 1987. Biochem. Pharmacol. 36: 3697-3700. PMID: 2823830
2. Giménez, R., et al. 1991. Br. J. Pharmacol. 104: 575-578. PMID: 1839138
3. Onal, M.Z., et al. 1997. Stroke. 28: 1060-1065. PMID: 9158650
4. Cavun, S. and Savci, V. 2004. Fundam Clin Pharmacol. 18: 513-523. PMID: 15482372
5. Yilmaz, Z., et al. 2010. Blood Coagul. Fibrinolysis. 21: 339-348. PMID: 20410813

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16211925
Merck Index :
14: 02319
MDL Number :
MFCD00150508
EC Number :
251-689-1
Beilstein Registry :
4110040
SMILES :
C[N+](C)(C)CCOP(=O)([O-])OP(=O)([O-])OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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