Cyproterone AcetateA compound that induces apoptosis in hepatocytes

Cyproterone Acetate (CAS 427-51-0)

Cyproterone Acetate | CAS 427-51-0 is rated 5.0 out of 5 by 1.
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Synonym: Androcur
Application: A compound that induces apoptosis in hepatocytes
CAS Number: 427-51-0
Purity: ≥98%
Molecular Weight: 416.94
Molecular Formula: C24H29ClO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cyproterone acetate has antagonistic properties towards the androgen receptor (IC50 = 7.1 nM). It can however, also act as a partial agonist of AR (EC50 = 4.0 μM). In the presence of 10 nM testosterone, low concentrations of cyproterone acetate inhibit T-stimulated transcription of 3XHRE-LUC, but at higher concentrations, transcription is stimulated. Cyproterone Acetate is also a hepatomitogen and tumor promoter and induces apoptosis in hepatocytes.


References

Kasper, P., Mueller, L. Carcinogenesis. 20:2185-8 (1999). Oberhammer, F.A., Pavelka, M., Sharma, S., et al. Proc. Natl Acad Sci, USA. 89:5408-12 (1992).

Physical State :
Solid
Solubility :
Soluble in water (partly), chloroform, methanol (50 mg/ml), DMSO (≥83 mg/ml at 25° C), and ethanol (≥10 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
200-201° C
IC50 :
Adenosine A1 receptor: IC50 = 5 nM (rat); Androgen receptor: IC50 = 7.1 nM; AR: IC50 = 23 nM (human); Progesterone receptor: IC50 = 37 nM (bovine); Androgen Receptor: IC50 = 47 nM (rat)
Ki Data :
Adenosine A1 receptor: Ki= 0.76 nM (rat); Progesterone receptor: Ki= 4.84 nM (bovine); AR: Ki= 14 nM (human); Androgen Receptor: Ki= 31 nM (rat); GR: Ki= 102 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GZ2230000
PubChem CID :
9880
Merck Index :
14: 2774
MDL Number :
MFCD00864671
EC Number :
207-048-3
Beilstein Registry :
2342172
SMILES :
CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)[C@@H]5C[C@@H]5[C@]34C)Cl)C)OC(=O)C

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Certificate of Analysis

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Cyproterone Acetate  Product Citations

See how others have used Cyproterone Acetate. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25811655  2015. PLoS ONE. 10: e0121316.

PMID: # 23089292  2012. Eur J Pharm Sci. 47: 842-7.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Takiguchi Takiguchi, M. et al. (PubMed 11551428) reported that Cyproterone Acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. -SCBT Publication Review
Date published: 2015-06-10
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