Cyproterone acetate has antagonistic properties towards the androgen receptor (IC50 = 7.1 nM). It can however, also act as a partial agonist of AR (EC50 = 4.0 μM). In the presence of 10 nM testosterone, low concentrations of cyproterone acetate inhibit T-stimulated transcription of 3XHRE-LUC, but at higher concentrations, transcription is stimulated. Cyproterone Acetate is also a hepatomitogen and tumor promoter and induces apoptosis in hepatocytes.
Kasper, P., Mueller, L. Carcinogenesis. 20:2185-8 (1999). Oberhammer, F.A., Pavelka, M., Sharma, S., et al. Proc. Natl Acad Sci, USA. 89:5408-12 (1992).
Soluble in water (partly), chloroform, methanol (50 mg/ml), DMSO (≥83 mg/ml at 25° C), and ethanol (≥10 mg/ml at 25° C).
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TakiguchiTakiguchi, M. et al. (PubMed 11551428) reported that Cyproterone Acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. -SCBT Publication Review
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