CyPPAAn activator of small conductance Ca2+ activated K+ channels

CyPPA (CAS 73029-73-9)

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Synonym: N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
Application: An activator of small conductance Ca2+ activated K+ channels
CAS Number: 73029-73-9
Molecular Weight: 285.39
Molecular Formula: C16H23N5
* Refer to Certificate of Analysis for lot specific data (including water content).
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CyPPA is an activator of small conductance Ca2+-activated K+ channels. Selective for KCNN2 (SK2) and SK3 channels, no selectivity for SK1 and IK channels.


References

Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655.

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), DMSO (100 mM), and water (slightly).
Storage :
Store at 4° C
Melting Point :
173.35° C (Predicted)
Boiling Point :
512.22° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
Ki Data :
Small conductance calcium-activated potassium channel protein 3: Ki= >50 µM (rat)
pK Values :
pKb: 4.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
909822
MDL Number :
MFCD01550586
SMILES :
CC1=CC(=NC(=N1)N2C(=CC(=N2)C)C)NC3CCCCC3

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Certificate of Analysis

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