cylindromatosis 1 Antibody (E-4) is a mouse monoclonal IgG2b (kappa light chain) provided at 200 µg/ml
raised against the C-terminal 419 amino acids of cylindromatosis 1 of human origin
cylindromatosis 1 Antibody (E-4) is recommended for detection of cylindromatosis 1 of mouse, rat and human origin by WB, IP, IF and ELISA
cylindromatosis 1 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of cylindromatosis 1 (E-4): sc-74434.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Familial cylindromatosis is an autosomal dominant genetic predisposition to multiple benign neoplasms of the skin known as cylindromas. These cylindromas may become infected, resulting in disfigurement and discomfort. In severe cases, ulcerated cylindromas are only treatable by reconstructive surgery with skin grafts. The human CYLD gene on chromosome 16q12.1 encodes the protein cylindromatosis 1. Mutations in this gene are responsible for familial cylindromatosis. The cylindromatosis 1 protein contains three cytoskeletal-associated protein-glycineconserved (CAP-GLY) domains and may function to coordinate the attachment of organelles to microtubules. Cylindromatosis 1 is expressed in brain, gonads, skeletal muscle, spleen, liver, heart, lung and leukocytes. Somatic mutations of the CYLD gene appear to play a role in the oncogenesis of tumors with cylindromatous features.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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