Cyclosporin DA potent inhibitor of tumor promoting phorbol ester TPA/PMA

Cyclosporin D (CAS 63775-96-2)

Cyclosporin D | CAS 63775-96-2 is rated 5.0 out of 5 by 1.
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Synonym: Val2-cyclosporin; 7-L-Valine-cyclosporin A
Application: A potent inhibitor of tumor promoting phorbol ester TPA/PMA
CAS Number: 63775-96-2
Purity: ≥95%
Molecular Weight: 1216.65
Molecular Formula: C63H113N11O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cyclosporin D is a weak immunosuppressor but potent inhibitor of tumor promoting phorbol ester TPA/PMA. Cyclosporin D also inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.


References

The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988)

Physical State :
Solid
Solubility :
Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6436250
SMILES :
CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O

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Certificate of Analysis

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Cyclosporin D  Product Citations

See how others have used Cyclosporin D. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27478032  Ma, C. et al. 2016. Antiviral Res. 133: 62-72.

Citations 1 to 1 of 1 total

What is the appearance of the chemical?

Asked by: two2igm05
Thanks for your question. Cyclosporin D, sc-204702, is a white crystal.
Answered by: TechService7
Date published: 2017-01-19
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Rated 5 out of 5 by from Gschwendt Gschwendt, M. et al.; BBRC 150, 545 (1988) found that Cyclosporin D (Val2-cyclosporin; 7-L-Valine-cyclosporin A) is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. -SCBT Publication Review
Date published: 2015-02-28
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