Cyclophosphamide-d4A DNA cross-linker

Cyclophosphamide-d4 (CAS 173547-45-0)

Cyclophosphamide-d4 | CAS 173547-45-0 is rated 5.0 out of 5 by 1.
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Synonym: ,N-Bis(2-chloroethyl)tetrahydro-4,5-d2-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide; Cycloblastin-d4;Cyclostin-d4
Application: A DNA cross-linker
CAS Number: 173547-45-0
Purity: ≥98%
Molecular Weight: 265.11
Molecular Formula: C7H11D4Cl2N2O2P
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cyclophosphamide-d4 is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1(ALDH1) activity.


References

Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

Physical State :
Solid
Solubility :
Soluble in Alcohol, Benzene, Chloroform, Dioxane and Ethylene Glycol
Storage :
Store at -20° C
Melting Point :
41-45° C
Boiling Point :
284.1-388.1° C at 760 mmHg (Predicted)
Density :
1.3±0.1 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3035226
SMILES :
[2H]C1(CC(OP(=O)(N1)N(CCCl)CCCl)([2H])[2H])[2H]

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Cyclophosphamide-d4  Product Citations

See how others have used Cyclophosphamide-d4. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 26971211  Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.

PMID: # 25124055  Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24825763  Gómez-Canela, C. et al. 2014. Analytical and bioanalytical chemistry. 406: 3801-14.

PMID: # 23313302  Gómez-Canela, C. et al. 2013. J Chromatogr A. 1276: 78-94.

PMID: # 23357749  Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Horino et al Horino et al. (PubMed ID 15935954) used Cyclophosphamide-d4 to induce gut-derived P. aeruginosa sepsis in IL-1-deficient mice and wild-type (WT) mice. -SCBT Publication Review
Date published: 2015-01-29
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