Cyclopamine-KAADCAS: 306387-90-6
MF: C44H63N3O4
MW: 698.0
A specific inihibtor of hedgehog signaling.

Cyclopamine-KAAD (CAS 306387-90-6)

Cyclopamine-KAAD | CAS 306387-90-6 is rated 5.0 out of 5 by 1.
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Application: A specific inihibtor of hedgehog signaling
CAS Number: 306387-90-6
Purity: ≥70%
Molecular Weight: 698.0
Molecular Formula: C44H63N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cyclopamine-KAAD is a potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity. Cyclopamine-KAAD binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Cyclopamine-KAAD also suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity.


References

Watkins, D.N., et al. 2003. Nature 422, 313. Berman, D.M., et al. 2002. Science 297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Chen, J.K., et al. 2002. Genes Dev. 16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. Taipale, J., et al. 2000. Nature 406, 1005.

Physical State :
Solid
Solubility :
Soluble in water (partly ), DMSO (5 mg/ml), methanol (1 mg/ml), and ethanol (1 mg/ml).
Storage :
Store at -20° C
Boiling Point :
875.60° C at 760 mmHg (Predicted)
Density :
1.16 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Hh signaling : IC50 = 20 nM (Shh-LIGHT2 assay); Hh signaling : IC50 = 50 nM (p2Ptch-/-cells)
pK Values :
pKb: 9.45 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5284327
SMILES :
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCC7=CC=CC=C7

Download SDS (MSDS)

Certificate of Analysis

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Cyclopamine-KAAD  Product Citations

See how others have used Cyclopamine-KAAD. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27010359  Fleury, A. et al. 2016. Sci Rep. 6: 23479.

PMID: # 25958162  Wang, S. et al. 2015. Eur Spine J. 24: 1720-8.

PMID: # 23555905  Ciucci, A. et al. 2013. PLoS ONE. 8: e60145.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Singh Singh, RR. Et al. (PubMed 19244133) demonstrated that inhibition of SHH/GLI1 signaling pathway by Cyclopamine-KAAD, as well as silencing GLI1 gene expression by small interfering RNA, decreased cell viability and clonogenicity of anaplastic lymphoma kinase-positive large cell lymphoma. -SCBT Publication Review
Date published: 2015-07-04
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