CyclocreatineAn antitumor biochemical and enzyme inhibitor for proteomics research

Cyclocreatine (CAS 35404-50-3)

Cyclocreatine | CAS 35404-50-3 is rated 5.0 out of 5 by 2.
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Synonym: 1-Carboxymethyl-2-iminoimidazolidine; 2-Imino-1-imidazolidineacetic acid
Application: An antitumor biochemical and enzyme inhibitor for proteomics research
CAS Number: 35404-50-3
Purity: ≥95%
Molecular Weight: 143.14
Molecular Formula: C5H9N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cyclocreatine is a building block and enzyme inhibitor used for proteomics research. Cyclocreatine can regulate creatine biosynthesis by suppressing the level of arginine: glycine amidinotransferase. Cyclocreatine is a protectant against inhibition of cardiac mitochondrial respiration.


References

1. Maril, N., et al., 1999. Kinetics of cyclocreatine and Na(+) cotransport in human breast cancer cells: mechanism of activity. The American journal of physiology. 277(4 Pt 1): C708-16. PMID: 10516101
2. Kornacker, M., et al., 2001. Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis. International journal of cancer. Journal international du cancer. 94(4): 513-9. PMID: 11745437
3. Martin, K., et al., 1996. Specific targeting of tumor cells by the creatine analog cyclocreatine. International journal of oncology. 9(5): 993-9. PMID: 21541606
4. Kurosawa, Yuko., et al., 2012. Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. The Journal of clinical investigation. 122(8): 2837-46. PMID: 22751104
5. Enrico, Adriano., et al., 2013. Electrophysiology and biochemical analysis of cyclocreatine uptake and effect in hippocampal slices. Journal of integrative neuroscience. 12(2): 285-97. PMID: 23869866

Physical State :
Solid
Solubility :
Soluble in Water
Storage :
Store at -20° C
Melting Point :
>300°C (lit.)(dec.)
Boiling Point :
~350.44° C at 760 (Predicted)
Density :
~1.6 g/cm3 (Predicted) (tautomer)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2896
SMILES :
C1CN(C(=N1)N)CC(=O)O

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Cyclocreatine  Product Citations

See how others have used Cyclocreatine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30174304  Kurmi, K. et al. 2018. Cell Metab.

Citations 1 to 1 of 1 total

Solubility in water?

Asked by: chemicalsmg
Thank you for your question. Cyclocreatine, sc-217984, is soluble in water at least 3 mg/mL.
Answered by: TechService7
Date published: 2016-12-28
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Rated 5 out of 5 by from It does improve microglia fitness and decreases neuronal dystrophy around areas of Ab deposition Potentially, in human it could ameliorate cognitive impairment
Date published: 2018-10-30
Rated 5 out of 5 by from Enrico et al Enrico et al. (PubMed ID 23869866) showed that cyclocreatine did not increase creatine content in in vitro hippocampal mouse slices because it blocked the creatine transporter. -SCBT Publication Review
Date published: 2015-03-16
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