Anti-cyclin T2a/b Antibody (2128C1a) is a mouse monoclonal IgG1cyclin T2a/b antibody, cited in 3 publications, provided at 100 µg/ml
raised against a recombinant protein corresponding to an internal region of cyclin T2a/b of human origin
recommended for detection of cyclin T2a and cyclin T2b of human origin by WB and IP
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of cyclin T2a/b (2128C1a): sc-81243.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for cyclin T2a/b Antibody (2128C1a) for WB applications. These reagents are now offered in bundles with cyclin T2a/b Antibody (2128C1a) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
cyclin T2a/b Antibody (2128C1a) is a high quality monoclonal cyclin T2a/b antibody (also designated cyclin T2 antibody or CCNT2 antibody) suitable for the detection of the cyclin T2a/b protein of human origin. cyclin T2a/b Antibody (2128C1a) is available as the non-conjugated anti-cyclin T2a/b antibody. Cyclin T1 was identified as a partner for Cdk9, an RNA polymerase II (RNAPII) transcription elongation factor. Cyclin T1 interacts with the transactivation domain of the HIV-1 Tat protein. The interaction of Tat with cyclin T1 enhances the affinity of Tat for the viral TAR RNA stem-loop structure, suggesting that Tat can recruit cyclin T1/cdk9 to RNAPII through cooperative binding to TAR. The human positive transcription elongation factor b (P-TEFb) consists of a cyclin dependent kinase, cdk9, paired with a cyclin T. Cdk9 may be paired with either cyclin T1 or cyclin T2, in a mutually exclusive manner. Two forms of cyclin T2, T2a and T2b, are due to alternative splicing. The binding of Tat to TAR was shown to be facilitated by human cyclin T1, but not by cyclins T2a or T2b. Cyclin T2 binds to Cdk9 but not to Tat, and cyclin T2 can inhibit cyclin T1-mediated Tat activity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.