Curcumin (Synthetic), a phenolic pigment originally isolated from Curcuma longa (tumeric) has reported antioxident, anticancer and anti-inflammatory actvities as noted in multiple in vitro studies. A study investigating the effects of curcumin on reported inflammatory mediators in inflammatory bowel disease on colonic myofibroblasts obtained ex vivo reported that a dose-dependent suppression of matrix metalloproteinase-3 (MMP-3) occured. Additional studies report that Curcumin is able to suppress NF-κB, COX-1, COX-2 and TNF-α. Noted in research studies to upregulate PPARγ, p53 and Nrf2. Curcumin (Synthetic) is an inhibitor of 5-LO, Cox-2, CREB Binding Protein, GST, IKK, JNK, NF kappa B, NOS2, NQO1 and p300. Curcumin has been shown to modify histones. In one study, exposure of MCF7 cells to curcumin resulted in increased global levels of acetylated H3K18 and H4K16.
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