Curcumin (Synthetic)Reported to suppress COX-1, COX-2, NF-κB and other inflammatory mediators

Curcumin (Synthetic) (CAS 458-37-7)

Curcumin (Synthetic) | CAS 458-37-7 is rated 5.0 out of 5 by 1.
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Application: Reported to suppress COX-1, COX-2, NF-κB and other inflammatory mediators
CAS Number: 458-37-7
Purity: ≥95%
Molecular Weight: 368.38
Molecular Formula: C21H20O6
* Refer to Certificate of Analysis for lot specific data (including water content).

Curcumin (Synthetic), a phenolic pigment originally isolated from Curcuma longa (tumeric) has reported antioxident, anticancer and anti-inflammatory actvities as noted in multiple in vitro studies. A study investigating the effects of curcumin on reported inflammatory mediators in inflammatory bowel disease on colonic myofibroblasts obtained ex vivo reported that a dose-dependent suppression of matrix metalloproteinase-3 (MMP-3) occured. Additional studies report that Curcumin is able to suppress NF-κB, COX-1, COX-2 and TNF-α. Noted in research studies to upregulate PPARγ, p53 and Nrf2. Curcumin (Synthetic) is an inhibitor of 5-LO, Cox-2, CREB Binding Protein, GST, IKK, JNK, NF kappa B, NOS2, NQO1 and p300. Curcumin has been shown to modify histones. In one study, exposure of MCF7 cells to curcumin resulted in increased global levels of acetylated H3K18 and H4K16.


References

1. Asai, A. and Miyazawa, T. 2001. J. Nutr. 131: 2932-2935. PMID: 11694621
2. Hanai, H. and Sugimoto, K. 2009. Curr. Pharm. Des. 15: 2087-2094. PMID: 19519446
3. Epstein, J., et al. 2010. Br. J. Nutr. 103: 824-832. PMID: 19878610
4. Shehzad, A., et al. 2011. Eur J Nutr. [Epub ahead of print]. PMID: 21442412

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
186° C
Boiling Point :
591.36° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
pK Values :
pKa: 8.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MI5230000
PubChem CID :
969516
MDL Number :
MFCD00008365
EC Number :
207-280-5
Beilstein Registry :
2306965
SMILES :
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

Download SDS (MSDS)

Certificate of Analysis

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Curcumin (Synthetic)  Product Citations

See how others have used Curcumin (Synthetic). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29740418  Simpson, S. et al. 2018. Front Microbiol. 9: 788.

PMID: # 22847000  Narayanan, A. et al. 2012. The Journal of biological chemistry. 287: 33198-214.

Citations 1 to 2 of 2 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. This compound, Curcumin (Synthetic) (CAS 458-37-7): sc-294110, is soluble in 10 mg/mL of ethanol.
Answered by: Technical Support
Date published: 2016-12-14
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Rated 5 out of 5 by from Shehzad et al Shehzad et al. (PubMed ID 21442412) found that curcumin downregulated inflammatory cytokines, resistin, and leptin while upregulating adiponectin. -SCBT Publication Review
Date published: 2015-03-18
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