CTLL-2 Cell Lysate: sc-2242

The CTLL-2 Cell Lysate is derived from the CTLL-2 cell line, a murine T-cell line that is specifically cultured from cytotoxic T lymphocytes and is used extensively in immunological research. This cell line was originally established to support studies on the interleukin-2 (IL-2) dependency of T cells, offering a practical tool for examining T-cell proliferation and survival under various experimental conditions. The lysate itself encompasses a wide spectrum of cellular components, including proteins, nucleic acids, lipids, and other cellular metabolites, which are extracted through methods such as mechanical disruption, detergent lysis, or enzymatic processing. In research, CTLL-2 Cell Lysate has been invaluable for studying signal transduction pathways and cellular responses triggered by cytokines, particularly IL-2. It allows scientists to dissect the complex mechanisms of T-cell activation, differentiation, and function without delving into clinical or therapeutic contexts. Additionally, this lysate is utilized in proteomic studies to identify and analyze protein expression and to understand post-translational modifications within the cells. By providing a comprehensive profile of the proteins and other molecules in T cells, CTLL-2 Cell Lysate contributes significantly to fundamental research in immunology, enhancing our understanding of immune system dynamics and cellular communication pathways.

CTLL-2 Cell Lysate References:

1. Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice.  |  Ito, A., et al. 2001. Blood. 97: 2075-83. PMID: 11264174
2. Cytotoxic granules from killer cells: specificity of granules and insertion of channels of defined size into target membranes.  |  Criado, M., et al. 1985. J Immunol. 135: 4245-51. PMID: 2415607
3. Development of Conformational Antibodies to Detect Bcl-xL′s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells.  |  Gonneaud, A., et al. 2020. Int J Mol Sci. 21: PMID: 33076337
4. Monoclonal antibody 2B6-F2 identifies a subset of murine natural killer cells with receptors for YAC-1 and WEHI-164 targets.  |  Martiniello, R., et al. 1994. Cell Immunol. 156: 155-69. PMID: 8200033
5. Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1.  |  Kim, YJ., et al. 1993. J Immunol. 151: 1255-62. PMID: 8335927
6. Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases.  |  Fujita, N., et al. 1998. Oncogene. 17: 1295-304. PMID: 9771973