Cryptotanshinone

Cryptotanshinone (CAS 35825-57-1)

Cryptotanshinone | CAS 35825-57-1 is rated 5.0 out of 5 by 1.
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Synonym: Tanshinone c; 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione
Application: Inhibitor of STAT3 and AChE
CAS Number: 35825-57-1
Purity: ≥98%
Molecular Weight: 296.36
Molecular Formula: C19H20O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cryptotanshinone is a major tanshinone that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMPK (AMP-activated protein kinase). Also inhibits AChE (acetylcholinesterase) (IC50 = 4.09 μM) and reduction in Aβ peptide generation.

Physical State :
Solid
Solubility :
Soluble in DMSO (12 mg/ml at 25 °C), water (1 mg/ml at 25 °C), and ethanol (10 mg/ml at 25 °C).
Storage :
Store at room temperature
Melting Point :
176.33° C (Predicted)
Boiling Point :
459° C at 760 mmHg
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D -85.0°±3.0°, c = 0.1 in chloroform
IC50 :
SARS coronavirus 3C-like proteinase: IC50 = 0.8 µM (SARS coronavirus); AChE: IC50 = 4.09 µM (human); STAT3: IC50 = 4.6 µM; JAK2 phosphorylation: IC50 = ~5 µM; AGS: IC50 = 10.2 µM (human)
Ki Data :
CES2: Ki= 141 nM (human); CES1: Ki= 544 nM (human); AChE: Ki= 6.41 µM (human); SARS coronavirus 3C-like proteinase: Ki= 9 µM (SARS coronavirus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SF8282645
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
160254
MDL Number :
MFCD07636810
SMILES :
C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

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Certificate of Analysis

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Cryptotanshinone  Product Citations

See how others have used Cryptotanshinone. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28428003  Jiang, JX. et al. 2017. Biochim. Biophys. Acta. 1863: 1778-1788.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Xia et al Xia et al. (PubMed ID 26356271) showed that Cryptotanshinone combined with cisplatin induced apoptosis by sensitizing A549/DDP cells and inhibiting the Nrf2 pathway in chemoresistant carcinoma cells. -SCBT Publication Review
Date published: 2015-01-05
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