CP 96345CAS: 132746-60-2
MF: C28H32N2O
MW: 412.57
A selective and potent non-peptide NK1receptor antagonist.

CP 96345 (CAS 132746-60-2)

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Synonym: (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
Application: A selective and potent non-peptide NK1receptor antagonist
CAS Number: 132746-60-2
Purity: ≥98%
Molecular Weight: 412.57
Molecular Formula: C28H32N2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CP 96345 is a selective and potent non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation.


References

1. Snider, R.M., et al. 1991. Science. 251: 435-437. PMID: 1703323
2. Lembeck, F., et al. 1992. Br. J. Pharmacol. 105: 527-530. PMID: 1378337
3. Bang, R., et al. 2003. J. Pharmacol. Exp. Ther. 305: 31-39. PMID: 12649350

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (24 mg/ml).
Storage :
Store at room temperature
Melting Point :
219.07° C (Predicted)
Boiling Point :
~541.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
NK-1R: IC50 = 0.2 nM (human); Neurokinin 1 receptor: IC50 = 0.4 nM (guinea pig); U373 MG: IC50 = 9 nM (human); Neurokinin 1 receptor: IC50 = 24 nM (mouse); Neurokinin 1 receptor: IC50 = 32 nM (rat)
Ki Data :
NK-1R: Ki= 0.4 nM (human); U11 MG: Ki= 4 nM (human)
pK Values :
pKb: 9.99 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CL5594350
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
104943
MDL Number :
MFCD00900615
SMILES :
COC1=CC=CC=C1CN[[email protected]@H]2[[email protected]@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5

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Certificate of Analysis

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CP 96345  Product Citations

See how others have used CP 96345. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31273787  Morioka, N.|Miyauchi, K.|Miyashita, K.|Kochi, T.|Zhang, FF.|Nakamura, Y.|Liu, K.|Wake, H.|Hisaoka-Nakashima, K.|Nishibori, M.|Nakata, Y.| et al. 2019. J. Neurochem.

Citations 1 to 1 of 1 total
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