CP-55,940A potent non-selective cannabinoid receptor agonist

CP-55,940 (CAS 83002-04-4)

CP-55,940 | CAS 83002-04-4 is rated 5.0 out of 5 by 1.
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Synonym: 5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol
Application: A potent non-selective cannabinoid receptor agonist
CAS Number: 83002-04-4
Purity: ≥98%
Molecular Weight: 376.6
Molecular Formula: C24H40O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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CP-55940 is a cannabimimetic small molecule and a potent cannabinoid receptor agonist, demonstrating similar binding activity at both receptor types (CB1 Ki=0.58 nM, CB2 Ki=0.69 nM). CP-55940 represents a useful non-selective agonist entry into the growing library of synthetic cannabimimetics, compounds which are being actively explored for efficacy in perturbing Alzheimer's disease and other neurodegenerative states.


References

1. Showalter, V.M., et al. 1996. J. Pharmacol. Exp. Ther. 278: 989-999. PMID: 8819477
2. Rinaldi-Carmona, M., et al. 1996. Life Sci. 58: 1239-1247. PMID: 8614277
3. Thomas, B.F., et al. 1998. J. Pharmacol. Exp. Ther. 285: 285-292. PMID: 9536023

Physical State :
Solid
Solubility :
Soluble in ethanol, DMSO and DMF all at ~30 mg/ml. Sparingly soluble in aqueous buffers, ethanol:PBS (1:3, pH 7.2, 0.25 mg/ml).
Storage :
Store at -20° C
Melting Point :
212.69° C
Boiling Point :
~494.4° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.53
IC50 :
CB1: EC5050 = 0.2 nM; CB2: EC5050 = 0.3 nM; GRP55: EC5050 = 5 nM; Cannabinoid CB2 receptor: IC50 = 0.82 nM (human); Cannabinoid CB1 receptor: IC50 = 0.77 nM (human)
Ki Data :
recombinant CB1 : Ki= 0.58 nM (human); recombinant CB2: Ki= 0.69 nM (human)
pK Values :
pKa: 10.25
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SL1955000
Transport :
Regional sales restrictions may apply.
PubChem CID :
104895
MDL Number :
MFCD00673965
SMILES :
CCCCCCC(C)(C)C1=CC(=C(C=C1)[C@@H]2C[C@@H](CC[C@H]2CCCO)O)O

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Certificate of Analysis

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CP-55,940  Product Citations

See how others have used CP-55,940. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27640887  Ortega, A. et al. 2016. Life Sci. 165: 56-62.

Citations 1 to 1 of 1 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Sparingly soluble in aqueous buffers, ethanol:PBS (1:3, pH 7.2, 0.25 mg/ml). Soluble in DMSO and DMF at 30 mg/ml. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-21
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Rated 5 out of 5 by from Thomas et al Thomas et al. (PubMed ID 9536023) found that CP-55,940 was a cannabinoid agonist that directly interacted with cannabinoid binding sites in the rat brain. -SCBT Publication Review
Date published: 2015-01-02
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