CP 376395 hydrochloride CAS: 1013933-37-3
MF: C21H30N2•HCl
MW: 362.94
A CRF-RI receptor antagonist.

CP 376395 hydrochloride (CAS 1013933-37-3)

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Synonym: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
Application: A CRF-RI receptor antagonist
CAS Number: 1013933-37-3
Molecular Weight: 362.94
Molecular Formula: C21H30N2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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CP 376395 hydrochloride is a CRF-RI receptor antagonist which is potent and selective (Ki values are 12 and >10000 nM for CRF-RI and CRF-RII receptors respectively).


Chen et al (2008) 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 51 1385

Physical State :
Solubility :
Soluble in water (50 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
Corticotropin releasing factor receptor 1: IC50 = 5.1 nM (rat)
Ki Data :
CRF1 receptor: Ki= 12 nM; CRF2 receptor: Ki= >10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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Can I store CP at room temperature following water solubilization?

Asked by: Thiago
Thank you for your question. In general, we recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Wherever possible solutions should be made up and used on the same day.
Answered by: Technical Support
Date published: 2017-10-31
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