Coumarin-SAHAA fluorescent probe that competitively binds HDAC

Coumarin-SAHA (CAS 1260635-77-5)

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Synonym: Coumarin Suberoylanilide Hydroxamic Acid; N1-Hydroxy-N8-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)octanediamide
Application: A fluorescent probe that competitively binds HDAC
CAS Number: 1260635-77-5
Molecular Weight: 346.38
Molecular Formula: C18H22N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Coumarin-SAHA is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8. This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (~5 mg/ml), DMF (~5 mg/ml), and 1:9 solution of DMF:PBS (pH 7.2) (~0.1 mg/ml).
Storage :
Store at -20° C
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Fluoresence :
λex 325 nm, λem 400 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53393956
SMILES :
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO

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Certificate of Analysis

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