Coumarin 6 CAS: 38215-36-0
MF: C20H18N2O2S
MW: 350.43

Coumarin 6 (CAS 38215-36-0)

Coumarin 6 | CAS 38215-36-0 is rated 5.0 out of 5 by 1.
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Alternate Names: Coumarin 6 is known as a fluorochrome laser dye.
Application: Coumarin 6 is a fluorescent probe and Laser dye widely used for staining polymer particles, organelles, or other materials used in medicine.
CAS Number: 38215-36-0
Purity: >98%
Molecular Weight: 350.43
Molecular Formula: C20H18N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Coumarin 6 is a fluorescent probe and Laser dye with a Dye content of 98%. In fluorescence spectroscopy, Coumarin 6 is reported to be the most stable for its performance in lifetime experiments. Coumarin 6 may be used to calibrate fluorescence imaging microscopy systems. As a fluorescent probe, Coumarin 6 may conduct in vivo tracking, cell uptake, and mechanistic studies of microparticle drug delivery systems. Coumarin 6 is a member of 7-aminocoumarins and has a role as a fluorochrome.


References

1. J. Eley et al.: J. McLane: Drug Delivery 11(4), 255 (2004) ,
2. J. Panyam et al.: Int. J. Pharm. 262(1-2), 1 (2003) ,
3. C. Lombry et al.: J. Contr. Release, 83(3), 331 (2002)
4. Regina Won Kay Leung et. al
Biomedical optics express, 2(9), 2517-2531 (2011-10-13)
5. Xin Guan et. al
Drug delivery, 23(9), 3307-3318 (2016-4-14)
6. Elizebeth Purr, et al. Preparation of PLGA Nanoparticles Encapsulated with Fluorescent Probe Coumarin-6. bioRxiv preprint first posted online Apr. 23, 2019.

Appearance :
Powder or crystalline powder
Physical State :
Solid
Solubility :
Soluble in ethanol, methanol, and N,N-DMF (almost transparency). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
208-210° C (lit.)
Boiling Point :
~570.1° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
NIH3T3: IC50 = > 70 µM (mouse); HUVEC50: IC50 = > 70 µM (human); U-87 MG: IC50 = > 70 µM (human); SiHa: IC50 = > 70 µM (human); HeLa: IC50 = > 70 µM (human)
Fluoresence :
λex 444 nm, λem 505 nm in ethanol; λex 458 nm, λem 497 nm in methanol
pK Values :
pKb: 2.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00041869
EC Number :
253-830-2
Beilstein Registry :
1085798
SMILES :
CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NC4=CC=CC=C4S3

Download SDS (MSDS)

Certificate of Analysis

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Coumarin 6 (CAS 38215-36-0)  Product Citations

See how others have used Coumarin 6 (CAS 38215-36-0). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 31020458  Chan, PS.|Xian, JW.|Li, Q.|Chan, CW.|Leung, SSY.|To, KKW.| et al. 2019. AAPS J. 21: 59.

PMID: # 31515645  AAPS PharmSciTech. 307.

PMID: # 33391978  Nanotheranostics. 113-124.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Sun et al Sun et al. (PubMed ID 25999718) used Coumarin 6 to label polyethylene glycol-coated polylactic acid (PEG-PLA) stealth nanoparticles to study sustained drug release in guinea pigs. -SCBT Publication Review
Date published: 2015-05-04
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