Convulxin CAS: 37206-04-5
MW: ~84kDa.

Convulxin (CAS 37206-04-5)

Convulxin | CAS 37206-04-5 is rated 5.0 out of 5 by 2.
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Alternate Names: Convulxin also known as Factor X Activator-RVV
Application: Convulxin is a heterodimeric C-type lectin shown to activate mammalian platelets and can induce platelet prothrombinase activity
CAS Number: 37206-04-5
Purity: >90%
Molecular Weight: ~84kDa.
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Convulxin is a 72-kDa glycoprotein and a member of the heterodimeric C-type lectin family. Convulxin acts as a potent platelet activator and has been described to induce platelet prothrombinase activity. Data suggests that Convulxin induces the collagen signaling pathway to activate platelets by interacting with the p62/GPV receptor. Convulxin activates collagen receptor glycoprotein VI (GPVI) on platelets and initiates blood clotting. Additional studies suggest that Convulxin has the ability to enhance the tryosine phosphorylation of the platelet endothelial cell adhesion molecule-1 (CD31), and binds to native GPIb and GPVI.


References

1. Polgár, J., et al. 1997. J. Biol. Chem. 272: 13576-13583. PMID: 9153205

2. Jandrot-Perrus, M., et al. 1998. Platelets. 9: 207-211. PMID: 16793703

3. Cicmil, M., et al. 2000. J. Biol. Chem. 275: 27339-27347. PMID: 10858437

4. Kanaji, S., et al. 2003. J. Biol. Chem. 278: 39452-39460. PMID: 12881531

5. Batuwangala, T., et al. 2004. Acta Crystallogr. D Biol. Crystallogr. 60: 46-53. PMID: 14684891

Usage :
Assay performed in aggregometer

1. Incubate (5x108 platelets/ml) 485µl platelet suspension until base line is stable at 37°C for 1-2 minutes.

2. Add 5µl of 200mM CaCl2 and 5µl of 200mM MgCl2. Continue after base line is stable.

3. For a positive control add 5µl of collagen solution (0.5mg/ml) or 5µl convulxin (0.1µg/ml in HEPES).

4. Aggregation can be measured at 37°C.
Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Crotalus durissus terrificus snake venom.
Solubility :
Soluble in HEPES.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.

Download SDS (MSDS)

Certificate of Analysis

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Convulxin (CAS 37206-04-5)  Product Citations

See how others have used Convulxin (CAS 37206-04-5). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 33386737  Cho, JH.|Wool, GD.|Tjota, MY.|Gutierrez, J.|Mikrut, K.|Miller, JL.| et al. 2021. Am J Clin Pathol.

PMID: # 30614620  Lauritzen, B.|Olling, J.|Abel, KL.|Augustsson, C.|Balling, K.|Bjelke, M.|Hegelund, AC.|Hilden, I.| et al. 2019. J. Thromb. Haemost. 17: 460-469.

PMID: # 29321991  2018. J Tradit Complement Med. 8: 66-71.

PMID: # 29045015  Branchford, BR.|Stalker, TJ.|Law, L.|Acevedo, G.|Sather, S.|Brzezinski, C.|Wilson, KM.|Minson, K.|Lee-Sherick, AB.|Davizon-Castillo, P.|Ng, C.|Zhang, W.|Neeves, KB.|Lentz, SR.|Wang, X.|Frye, SV.|Shelton Earp, H.|DeRyckere, D.|Brass, LF.|Graham, DK.|Di Paola, JA.| et al. 2018. J. Thromb. Haemost. 16: 352-363.

PMID: # 28771279  Fidler, TP.|Rowley, JW.|Araujo, C.|Boudreau, LH.|Marti, A.|Souvenir, R.|Dale, K.|Boilard, E.|Weyrich, AS.|Abel, ED.| et al. 2017. Thromb. Haemost. 117: 1859-1867.

PMID: # 27631377  Modjeski, KL. et al. 2016. PLoS ONE. 11: e0160638.

PMID: # 26256688  Lambert, MP. et al. 2015. Journal of thrombosis and haemostasis : JTH. 13: 1888-99.

PMID: # 26295742  Duvernay, MT. et al. 2015. Biochemistry. 54: 5578-88.

PMID: # 25912149  Van Aelst, B. et al. 2015. Transfusion. 55: 2404-14.

PMID: # 24306059  Fuentes, E.|Badimon, L.|Caballero, J.|Padró, T.|Vilahur, G.|Alarcón, M.|Pérez, P.|Palomo, I.| et al. 2014. Thromb Haemost. 111: 491-507.

Citations 1 to 10 of 22 total

What percentage of BSA is recommended for use as a carrier protein?

Asked by: SCM4
For this chemical, Convulxin (CAS 37206-04-5), we recommend 0.1% BSA. We recommend adding a carrier protein such as BSA to the reconstitution buffer and any subsequent dilution buffers to prevent absorption on plastic surfaces.
Answered by: Technical Support
Date published: 2017-02-24

It's says soluble in HEPES, a bit vague. What molarity? what pH? Other solvents?

Asked by: c f
Convulxin is soluble in 10mM HEPES buffer, pH 7.2. We also recommend adding a carrier protein such as BSA to the reconstitution buffer and any subsequent dilution buffers to prevent absorption on plastic surfaces.
Answered by: Tech Service 11
Date published: 2017-02-23

Are there any storage recommendations for once the product is in solution?

Asked by: chemicalsmg
Thank you for your question. Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-22
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Rated 5 out of 5 by from Excellent Working fine for platelet aggregation in PRP and whole blood as well.
Date published: 2017-09-21
Rated 5 out of 5 by from Rochat Rochat, et al. (PubMed ID 25266200) used convulxin along with thrombin (in the presence of Annexin V-FITC and Calcium) to induce the expression of negatively charged phospholipids on the surface fraction of platelets. -SCBT Publication Review
Date published: 2015-04-09
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