ConessineA selective antagonist at the histamine H3-receptor

Conessine (CAS 546-06-5)

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Application: A selective antagonist at the histamine H3-receptor
CAS Number: 546-06-5
Purity: ≥97%
Molecular Weight: 356.59
Molecular Formula: C24H40N2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Conessine is a selective and potent histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid which displays in vitro antiplasmodial activity (IC50 = 1.04 μM). High affinity for α2C adrenoceptors (pKi = 7.98).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), ethanol (50 mM), and DMSO (50 mM).
Storage :
Store at room temperature
Melting Point :
125-127° C
Boiling Point :
450.43° C at 760 mmHg (Predicted)
Density :
1.05 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α20/D +19°, c = 1 in ethanol
IC50 :
Plasmodium falciparum : IC50 = 1.04 µM (Plasmodium falciparum K1)
Ki Data :
Histamine H3 receptor: Ki= 3.47 nM (human); α2C-AR: Ki= 10.47 nM (human); Histamine H3 receptor: Ki= 12.3 nM (rat); α2a-AR: Ki= 660.69 nM (human)
pK Values :
pKb: 10.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GK7621000
PubChem CID :
441082
MDL Number :
MFCD00016752
EC Number :
208-897-2
Beilstein Registry :
4702160
SMILES :
CC1C2CCC3[C@@]2(CCC4C3CC=C5[C@@]4(CCC(C5)N(C)C)C)CN1C

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Certificate of Analysis

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