Concanamycin C (CAS 81552-34-3)

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Application: Concanamycin C is a potent V-ATPase (vacuolar-type H⁺-ATPase) inhibitor

CAS Number: 81552-34-3

Purity: >96%

Molecular Weight: 823.1

Molecular Formula: C₄₅H₇₄O₁₃

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Concanamycin C is a potent vacuolar-type H⁺-ATPase inhibitor. Reports indicate that Concanamycins are 18-membered macrolide antibiotics that are active against yeast and fungi, and are effective at nanomolar concentrations. Isolation and characterization of Concanamycin C studies, show that it is also an effective inhibitor of Concanavalin A (sc-203007) induced mouse splenic lymphocyte.

References

1. Kinashi, H., et al. 1984. J. Antibiot. 37: 1333-1343. PMID: 6511660
2. Dröse, S., et al. 1993. Biochemistry. 32: 3902-3906. PMID: 8385991
3. Bowman, E.J., et al. 2000. J. Biol. Chem. 275: 167-176. PMID: 10617601
4. Dröse, S., et al. 2001. Biochemistry. 40: 2816-2825. PMID: 11258892

Physical State :

Solid

Derived From :

Streptomyces sp.

Solubility :

Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.

Storage :

Store at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

GK6887000

PubChem CID :

6441954

MDL Number :

MFCD00216692

Beilstein Registry :

6628190

SMILES :

CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)O)O)O)O)OC)C)C)O

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Certificate of Analysis

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