Concanamycin CA potent vacuolar-type H+-ATPase inhibitor

Concanamycin C (CAS 81552-34-3)

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Application: A potent vacuolar-type H+-ATPase inhibitor
CAS Number: 81552-34-3
Purity: >96%
Molecular Weight: 823.1
Molecular Formula: C45H74O13
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Concanamycin C is a potent vacuolar-type H+-ATPase inhibitor. Reports indicate that Concanamycins are 18-membered macrolide antibiotics that are active against yeast and fungi, and are effective at nanomolar concentrations. Isolation and characterization of Concanamycin C studies, show that it is also an effective inhibitor of Concanavalin A (sc-203007) induced mouse splenic lymphocyte.


References

1. Kinashi, H., et al. 1984. J. Antibiot. 37: 1333-1343. PMID: 6511660
2. Dröse, S., et al. 1993. Biochemistry. 32: 3902-3906. PMID: 8385991
3. Bowman, E.J., et al. 2000. J. Biol. Chem. 275: 167-176. PMID: 10617601
4. Dröse, S., et al. 2001. Biochemistry. 40: 2816-2825. PMID: 11258892

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GK6887000
PubChem CID :
6441954
MDL Number :
MFCD00216692
Beilstein Registry :
6628190
SMILES :
CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)O)O)O)O)OC)C)C)O

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Concanamycin C  Product Citations

See how others have used Concanamycin C. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22511765  Kim, H. et al. 2012. J. Biol. Chem. 287: 19029-39.

PMID: # 11258892  Dröse, S. et al. 2001. Biochemistry. 40: 2816-2825.

Citations 1 to 2 of 2 total
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