Concanamycin B

Concanamycin B (CAS 81552-33-2)

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Application: An antibiotic and inhibitor of vacuolar-type H+-ATPase
CAS Number: 81552-33-2
Purity: ≥96%
Molecular Weight: 852.1
Molecular Formula: C45H73NO14
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Concanamycin B (CMB) is an antibiotic that specifically inhibits vacuolar type H+-ATPase (V-ATPase). CMB has been reported to cause destruction of cytotoxic granules and inhibit acidification of intracellular organelles in cytotoxic T cells. Experiments show that exposure of cells to CMB along with epidermal growth factor has the potential to induce apoptosis.


References

1. Woo, J.T., et al. 1992. Eur. J. Biochem. 207: 383-389. PMID: 1628660
2. Lee, M.H., et al. 1995. Biosci. Biotechnol. Biochem. 59: 1417-1421. PMID: 7549091
3. Ito, K., et al. 1995. J. Antibiot. 48: 488-494. PMID: 7622435
4. Woo, J.T., et al. 1996. Biol. Pharm. Bull. 19: 297-299. PMID: 8850326
5. Lee, M.H., et al. 2000. Immunology. 99: 243-248. PMID: 10692043
6. Yoshimoto, Y. and Imoto, M. 2002. Exp. Cell Res. 279: 118-127. PMID: 12213220

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in chloroform, methanol, DMSO, and acetonitrile. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
960.18° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3462, Class 6.1, Packing group I
PubChem CID :
6440685
MDL Number :
MFCD01731919
SMILES :
CC=CC1C(C(CC(O1)(C(C)C(C(C)C2C(C=CC=C(CC(C(C(C(C(C=C(C=C(C(=O)O2)OC)C)C)O)C)O)C)C)OC)O)O)OC3CC(C(C(O3)C)OC(=O)N)O)C

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Certificate of Analysis

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