ColivelinA neuroprotective peptide and activator of STAT3

Colivelin (CAS 867021-83-8)

Colivelin | CAS 867021-83-8 is rated 5.0 out of 5 by 2.
  • y_2019, m_12, d_5, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_361153, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 70ms
  • REVIEWS, PRODUCT
5
2
4
0
3
0
2
0
1
0
Application: A neuroprotective peptide and activator of STAT3
CAS Number: 867021-83-8
Molecular Weight: 2645.13
Molecular Formula: C119H206N32O35
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Colivelin is a neuroprotective peptide and activator of STAT3. It is able to protect neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. It also suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and improves memory impairment in Alzheimer's disease (AD) models.

Physical State :
Solid
Sequence :
SALLRSIPAPAGASRLLLLTGEIDLP; H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - Pro - Ala - Gly - Ala - Ser - Arg - Leu - Leu - Leu - Leu - Thr - Gly - Glu - Ile - Asp - Leu - Pro - OH
Solubility :
Soluble in 30% acetonitrile / water (1 mg/ml).
Storage :
Store at -20° C
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD08704663
SMILES :
CC[C@@H](C)[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H]3CCCN3C(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@@H](CO)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Colivelin  Product Citations

See how others have used Colivelin. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 29708510  Ubil, E. et al. 2018. J. Clin. Invest. 128: 2356-2369.

PMID: # 30323565  Chen, L. et al. 2018. Drug Des Devel Ther. 12: 3335-3342.

PMID: # 26045134  Quévrain, E. et al. 2016. Gut. 65: 415-25.

PMID: # 31630150  Med. Sci. Monit. 25: 7853-7863.

PMID: # 31452742  Oncol Lett. 18: 2554-2559.

Citations 1 to 5 of 5 total

Is Colivelin specific for the activation of STAT3, and what else transcription factors are activated by Colivelin?

Asked by: boc_111
It is a STAT3 activator; also protects against β-amyloid neurotoxicity, but we do not know more about this. Here is some literature that may be helpful: Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vit J.Neurosci. 25 10252 PMID: 16267233 Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653 PMID: 19782727 Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020 PMID: 17928813
Answered by: Technical Support
Date published: 2019-09-27

Is this soluble in DMSO?

Asked by: chemsd02
Thank you for your question. sc-361153 (Colivelin, CAS# 867021-83-8) is hydrophobic. DMSO is a good choice for a solvent. Our recommended concentration is 1 mg/mL.
Answered by: Chemical Support 10
Date published: 2018-05-08
  • y_2019, m_12, d_5, h_12CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_361153, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 73ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Induce RANKL expression in murine osteoblasts This product (0.1 or 1.0 μM) induce RANKL expression in primary calvarial cells in mice. PLoS ONE 12(7):e0181126 · July 2017
Date published: 2017-08-04
Rated 5 out of 5 by from Wu et al Wu et al. (PubMed ID 25332198) showed that colivelin (CLN) exhibited neurotprotective properties against the neurotoxic effects of Alzheimer s disease by inhibiting hippocampal A 25-35 in rats. -SCBT Publication Review
Date published: 2015-02-24
  • y_2019, m_12, d_5, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_361153, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.