Colivelin is a neuroprotective peptide and activator of STAT3. It is able to protect neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. It also suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and improves memory impairment in Alzheimer's disease (AD) models.
SALLRSIPAPAGASRLLLLTGEIDLP; H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - Pro - Ala - Gly - Ala - Ser - Arg - Leu - Leu - Leu - Leu - Thr - Gly - Glu - Ile - Asp - Leu - Pro - OH
Soluble in 30% acetonitrile / water (1 mg/ml).
Store at -20° C
1.42 g/cm3 (Predicted)
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Is Colivelin specific for the activation of STAT3, and what else transcription factors are activated by Colivelin?
Asked by: boc_111
It is a STAT3 activator; also protects against β-amyloid neurotoxicity, but we do not know more about this. Here is some literature that may be helpful:
Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vit J.Neurosci. 25 10252 PMID: 16267233
Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653 PMID: 19782727
Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020 PMID: 17928813
Answered by: Technical Support
Date published: 2019-09-27
Is this soluble in DMSO?
Asked by: chemsd02
Thank you for your question. sc-361153 (Colivelin, CAS# 867021-83-8) is hydrophobic. DMSO is a good choice for a solvent. Our recommended concentration is 1 mg/mL.
Rated 5 out of
Induce RANKL expression in murine osteoblastsThis product (0.1 or 1.0 μM) induce RANKL expression in primary calvarial cells in mice. PLoS ONE 12(7):e0181126 · July 2017
Date published: 2017-08-04
Rated 5 out of
Wu et alWu et al. (PubMed ID 25332198) showed that colivelin (CLN) exhibited neurotprotective properties against the neurotoxic effects of Alzheimer s disease by inhibiting hippocampal A 25-35 in rats. -SCBT Publication Review
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