Colchicine-d3An isotopically labeled antimitotic agent

Colchicine-d3

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Synonym: Colsaloid-d3
Application: An isotopically labeled antimitotic agent
Molecular Weight: 402.46
Molecular Formula: C22H22D3NO6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Colchicine-d3 is an isotopically labeled antimitotic agent that disrupts microtubles by binding to Tubulin and preventing its polymerization. Induces apoptosis in several normal and tumor cell lines. Stimulates the intrinsic GTPase activity of Tubulin.


References

1. Lunduena, R.F., et al. 1992. Curr. Opin. Cell Biol. 4: 53-57. PMID: 1558754
2. Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-3783. PMID: 9427370
3. Want, T.H., et al. 1998. J. Biol. Chem. 273: 4928-4936. PMID: 9478937
4. Andreu, J.M., et al. 1998. Biochemistry. 37: 8356-8368. PMID: 9622487

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in Dichloromethane and Methanol
Storage :
Store at -20° C
Melting Point :
139-143° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
GH0700000
PubChem CID :
45038707
SMILES :
[2H]C([2H])([2H])C(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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