Colcemid, a cell sychronizing agent, has been reported to induce coordination of nuclear and cytoplasmic events during cell growth. At different concentrations, this compound has been shown to disrupt cell cycle integration and increase cell size. Colcemid depolarizes microtubules and inactivates spindle fiber formation, thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.
1. Sherwood, S.W., et al. 1994. Exp. Cell Res. 215: 373-379. PMID: 7982475 2. Kanda, R., et al. 1994. J. Radiat. Res. 35: 41-47. PMID: 8057270 3. Urbani, L., et al. 1995. Exp. Cell Res. 219: 159-168. PMID: 7628532
Soluble in ethanol, DMSO, chloroform (10 mg/ml), water, ether, benzene, and acidified water.
Rated 5 out of
LeeLee, J. et al. (PubMed 25982990) examined the effects of Colcemid, a cell synchronizing, anti-tubulin agent, treatment during oocyte in vitro maturation (IVM) and embryonic development after parthenogenetic activation (PA) and somatic-cell nucleus transfer (SCNT) in pigs. Their results suggest that the presence of Colcemid during the early stage of IVM stimulates preimplantation development of PA and SCNT porcine embryos by improving the cytoplasmic microenvironment. -SCBT Publication Review
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