Coenzyme Q10 is an electron transport chain component of the mitochondria, which assists proton and electron transfer across the inner mitochondrial membrane. Studies indicate that Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS3 (endothelial nitric oxide synthase, eNOS) and up-regulation of NOS2 (inducible nitric oxide synthase, iNOS). As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes.
1. Tsai, K.L., et al. 2011. J Nutr Biochem. [Epub ahead of print]. ,PMID: 21684136 2. Bogeski, I., et al. 2011. J. Am. Chem. Soc. 133: 9293-9303. PMID: 21548646
Soluble in water (partly), ethanol (5 mM), chloroform (50 mg/ml), and DMF (~10 mg/ml).
Store at -20° C
~869.0° C at 760 mmHg (Predicted)
~1.0 g/cm3 (Predicted)
n20D 1.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
BelousovaBelousova, MA. et al. (PubMed 26371950) reported that intravenous treatment with Coenzyme Q10 improves neurological outcome and reduces infarct volume after transient focal brain ischemia in rats. -SCBT Publication Review
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