Coenzyme Q10A mitochondrial transporter chain component

Coenzyme Q10 (CAS 303-98-0)

Coenzyme Q10 | CAS 303-98-0 is rated 5.0 out of 5 by 1.
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Synonym: CoQ10; Ubidecarenone; Ubiquinone-10; Q-10
Application: A mitochondrial transporter chain component
CAS Number: 303-98-0
Purity: ≥98%
Molecular Weight: 863.37
Molecular Formula: C59H90O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Coenzyme Q10 is an electron transport chain component of the mitochondria, which assists proton and electron transfer across the inner mitochondrial membrane. Studies indicate that Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS3 (endothelial nitric oxide synthase, eNOS) and up-regulation of NOS2 (inducible nitric oxide synthase, iNOS). As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes.


References

1. Tsai, K.L., et al. 2011. J Nutr Biochem. [Epub ahead of print]. ,PMID: 21684136
2. Bogeski, I., et al. 2011. J. Am. Chem. Soc. 133: 9293-9303. PMID: 21548646

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), ethanol (5 mM), chloroform (50 mg/ml), and DMF (~10 mg/ml).
Storage :
Store at -20° C
Melting Point :
48-52° C
Boiling Point :
~869.0° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DK3900000
PubChem CID :
5281915
Merck Index :
14: 9843
MDL Number :
MFCD00042919
EC Number :
206-147-9
Beilstein Registry :
1900141
SMILES :
CC1=C(C(=O)C(=C(C1=O)OC)OC)C/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CCC=C(C)C

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Coenzyme Q10, sc-205262, is a yellow to orange crystalline powder
Answered by: TechService7
Date published: 2017-01-16
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Rated 5 out of 5 by from Belousova Belousova, MA. et al. (PubMed 26371950) reported that intravenous treatment with Coenzyme Q10 improves neurological outcome and reduces infarct volume after transient focal brain ischemia in rats. -SCBT Publication Review
Date published: 2015-05-01
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