CNQX disodium saltA competitive kainate/quisqualate receptor antagnoist

CNQX disodium salt (CAS 115066-14-3 (non-salt))

CNQX disodium salt | CAS 115066-14-3 (non-salt) is rated 5.0 out of 5 by 1.
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Synonym: 6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Application: A competitive kainate/quisqualate receptor antagnoist
CAS Number: 115066-14-3 (non-salt)
Molecular Weight: 276.12
Molecular Formula: C9H2N4O42Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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CNQX disodium salt is a potent and competitive GluR (kainate/quisqualate (non-NMDA) receptor) antagonist. It also shows antagonism of the NMDA receptor at the glycine modulatory site. It is a more water soluble form of CNQX.


References

1. Honoré, T., et al. 1988. Science. 241: 701-703. PMID: 2899909
2. Long, S.K., et al. 1990. Br. J. Pharmacol. 100: 850-854. PMID: 1976402
3. Watkins, J.C., et al. 1990. Trends Pharmacol. Sci. 11: 25-33. PMID: 2155495
4. King, A.E., et al. 1992. Br. J. Pharmacol. 107: 375-381. PMID: 1358390

Physical State :
Solid
Solubility :
Soluble in water (50 mM).
Storage :
Store at -20° C
Boiling Point :
659.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.79 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
VD1520000
PubChem CID :
6093155
MDL Number :
MFCD00801053
SMILES :
C1=C(C(=CC2=C1N=C(C(=N2)[O-])[O-])[N+](=O)[O-])C#N.[Na+].[Na+]

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Certificate of Analysis

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CNQX disodium salt  Product Citations

See how others have used CNQX disodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24366601  Takemoto, Y. et al. 2014. Amino Acids. 46: 863-72.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Al R; et al Al R; et al. (PubMed ID: 26409118) determined CNQX that disodium salt induced similar TrkB expression levels, however it accounted for a moderate decrease of Hsp70 mRNAs in the same brain areas in hampsters. -SCBT Publication Review
Date published: 2015-03-26
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