CMP-Sialic Acid, Monosodium SaltA toxin/gonococci protector; blood regulator

CMP-Sialic Acid, Monosodium Salt (CAS 3063-71-6)

CMP-Sialic Acid, Monosodium Salt | CAS 3063-71-6 is rated 5.0 out of 5 by 1.
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Synonym: CMP-N-Acetylneuraminic Acid, Na
Application: A toxin/gonococci protector; blood regulator
CAS Number: 3063-71-6
Purity: ≥85%
Molecular Weight: 636.43
Molecular Formula: C20H30N4O16P·Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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CMP-sialic acid, Monosodium salt is the active form of sialic acid. In mammalian cells it has been shown to be required for the biosynthesis of sialic acid-containing complex carbohydrates. Loss of CMP sialic acid, Monosodium salt production or the feed back inhibitor of CMP-sialic acid has lead to gram scale production of sialic acid by GLCNE (GNE, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase). The compound has demonstrated the ability to neutralize various toxins through masking binding sites. CMP-sialic acid, Monosodium salt has also provided protection against gonococci by siaylation of Gal beta 1-4GlcNAc group. Catalyzed through a surface sialyl-transferase, CMP-Sialic Acid, Monosodium Salt enhanced the responsiveness of insulin. The compound has also displayed function in blood protein half-life regulation, protection against glycoprotein lysis and cellular adhesion. CMP-Sialic Acid, Monosodium Salt is a substrate of Sialyltransferase.


References

1. Gottlieb, C. and Kornfeld, S. 1976. J. Biol. Chem. 251: 7761-7768. PMID: 1002711
2. Salhanick, A.I. and Amatruda, J.M. 1988. Am. J. Physiol. 255: E173-E179. PMID: 3407769
3. Parsons, N.J., et al. 1994. Microb. Pathog. 16: 413-421. PMID: 7830528
4. Bork, K., et al. 2005. FEBS Lett. 579: 5079-5083. PMID: 16137682

Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23679065
MDL Number :
MFCD00151579
SMILES :
CC(=O)N[C@@H]1[C@H](C[C@](OC1[C@@H]([C@@H](CO)O)O)(C(=O)O)OP(=O)([O-])OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC(=NC3=O)N)O)O)O.[Na+]

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Certificate of Analysis

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Rated 5 out of 5 by from Viswanathan Viswanathan, K. et al. (PubMed 26082222) describe a method to engineer CMP-Sialic Acid (toxin/gonococci protector) synthesis capability into Spodoptera frugiperda (Sf9) cells, a prototypical insect cell line, by recombinant expression of sialic acid synthesis pathway genes using baculovirus technology. Co-expression of a sialuria mutant UDP-GlcNAc-2-epimerase/ManNAc kinase (EKR263L), wild-type sialic acid 9-phosphate synthase (SAS), and wild-type CMP-sialic acid synthetase (CSAS) in the presence of GlcNAc leads to synthesis of CMP-sialic acids synthesis to support sialylation of N-glycans on glycoproteins. -SCBT Publication Review
Date published: 2015-01-25
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