Cloxacillin is a semi-synthetic β-lactam antibiotic, related to penicillin, which suppresses the growth of gram-positive bacteria such as Staphylococcus by inhibiting the synthesis of peptidoglycan. Furthermore, cloxacillin inactivates the enzyme β-lactamase I, a side product produced by bacteria that are resistant to β-lactam antibiotics, by causing the acyl form of the enzyme to unfold. Escherichia coli containing plasmids carrying non-coding DsrA RNA are resistant to Cloxacilin. Cloxacillin sodium is an inhibitor of LACTB.
1. Sabath, L.D., et al. 1976. Antimicrob. Agents Chemother. 9: 962-969. PMID: 938025 2. Kiener, P.A., et al. 1980. Eur. J. Biochem. 109: 575-580. PMID: 6773776 3. Rasmussen, B.A., et al. 1994. Antimicrob. Agents Chemother. 38: 2078-2085. PMID: 7811022 4. Nishino, K., et al. 2010. J. Antimicrob. Chemother. [Epub ahead of print]. PMID: 21088020
Soluble in water (55 mg/ml at 25° C), alcohol (1:30), methanol, ethanol (25 mg/ml at 25° C), and DMSO (55 mg/ml at 25° C).
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